The Elucidation of Thrombus Formation and the Application to Novel Monitoring in Cardiopulmonary Bypass Surgery

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After cardiopulmonary bypass (CPB) surgery, platelet concentration is the mainstay approach for hemostasis. The cut-off value and its monitoring, however, are not established in clinical practice. This study is conducted to investigate the interaction between platelet number and platelet function in the blood flow. In result, CPB caused the depletion in platelet count after hemodilution and inhibition of platelet function. We also observed the anticonagulants affect platelet thrombus formation by low thrombin generation on thrombus surface in flow condition. In conclusion, blood flow should be included on the development of novel monitoring apparatus for the perioperative bleeding.