The development of polysaccharide-encapsulated liposomes as vaccines against fungal infections

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Our laboratory has long been working on the liposomes with respect to immunological approaches. In the course of our study, we have already found that a nasal administration of the cationic liposomes with protein antigens dramatically enhanced both antigen-specific mucosal and systemic immune responses, namely the cationic liposome acts as a potent mucosal adjuvant in mice. In this study, we examined mucosal adjuvant activity of the cationic liposome against fungal polysaccharide antigens in order to overcome fungal infections. We first prepared polysaccharide antigens-encapsulated cationic liposomes, and then DBA/2 or BALB/c mice were immunized intranasally once a week with polysaccharide antigen-encapsulated cationic liposomes. Our study shows that intranasal vaccination with the polysaccharide antigen-encapsulated cationic liposomes significantly exerted polysaccharide antigen-specific antibody productions in DBA/2 mice, but not in BALB/c mice.