Role of Schnurri-3 for immune response

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Schnurri-3 (Shn-3) is an essential molecule for the early stage of Th2 differentiation for regulation of IL-4 production by AP-1. Upon immunization with antigen, T cell-specific Shn-3 conditional knockout (Shn-3 TKO) mice had low IgE production compared to immunized control mice. Moreover, when CD4+CD62L+ naive T cells were cultured under condition to promote Th17 differentiation, Shn-3-deficient CD4+T cells differentiated to a Th17 phenotype more frequently than control CD4+T cells. Furthermore, Shn-3-TKO mice exhibited intense exacerbation of development and progression of T cell-mediated autoimmune disease EAE. These data suggest that Schnurri-3 plays an important role in determining the phenotype of helper T cells during an immunoresponse.