Whole genome characterization of rotavirus strains circulating during a clinical trial of human rotavirus vaccine in Nha Trang, Vietnam.

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In an attempt to get insight into the cause of lower efficacy of rotavirus vaccines in developing countries, whole genome analysis was performed on G1P[8] and G3P[8] strains that predominated during a clinical trial of the pentavalent rotavirus vaccine in Vietnam. Their genotype constellation was found to be G1/G3-P[8]-I1-R1-C1-M1-A1-N1-T1-E1-E1-H1. Taken together with the result of the phylogenetic analysis, it was concluded that rotavirus strains circulating in Vietnam was no more different than the strains circulating in high-income countries. Thus, the lower efficacy is unlikely to be explained by the diversity of circulating strains.