Temporal imaging of epileptic activity in animal models

动物模型中癫痫活动的时间成像

• 批准号: 25893266
• 负责人: TSUCHIYA KOMEI
• 金额: $ 0.5万
• 依托单位: Soka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Research Activity Start-up
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-08-30 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-25893266/
• 关键词: てんかんモデル; 内因性信号; キンドリング; 脳血流画像

In this study, we measured the alteration of cerebral blood flow (CBF) during epileptiform seizure induced by acute kindling and drug injection of the mouse and rat hippocampus to reveal the progression of epileptic activity. In consequence, we found cingulate gyrus might mediate propagation of epileptiform seizure for motor cortex. Additionally, it was confirmed alteration of CBF during epileptiform seizure occured bilaterally. It was suggested that metaboric change caused by epileptiform seizure might occur bilaterally and accompany change of local filed potentials.

本研究通过测定小鼠和大鼠海马急性点燃和药物注射诱发癫痫样发作时脑血流量的变化，揭示癫痫活动的发展过程。因此，我们发现扣带回可能介导癫痫样发作向运动皮质的传播。此外，证实癫痫样发作时CBF的改变是双侧性的。结果提示，癫痫样发作引起的代谢性改变可能是双侧性的，并伴有局部场电位的改变。