权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Studies on production of taxol (anticancer agent) from natural sources.

从天然来源生产紫杉醇（抗癌剂）的研究。

基本信息

批准号：
09556033
负责人：
KIKUCHI Yoshinari
金额：
$ 7.74万
依托单位：
Institute of wood technology, Akita prefectural University (1999-2000)Akita Prefectural College of Agriculture (1997-1998)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

项目摘要

Taxol is one of the most promising natural-product anti-cancer drugs and has been shown to be effective in the treatment of ovarian, breast and lung cancers. Taxol, a diterpene found in Taxus spp., is found in Taxus cuspidata Sieb. Et Zucc., which grows in Japan. Although the demand for taxol is steadily increasing, the supply of the drug is limited. We performed studies to establish a method of extracting taxol from cultivated T.cuspidata trees. From these results, it was considered possible to extract taxol from forest resources. Extraction of taxol from renewable resources such as seedlings of T.cuspidata on short-rotation intensive-culture plantations was considered to be an attractive approach for the production of taxol in Japan. In summary, the contents of taxol, baccatin III and 10-deacetylbaccatin III in T.cuspidata growing in Japan were examined, and an efficient extraction method to produce taxol from forest resources was developed. The possibility of producing taxol from the forest resources as part of the forest administrat ion policy was suggested.

紫杉醇是最有前途的天然抗肿瘤药物之一，已被证明对卵巢癌、乳腺癌和肺癌有效。紫杉醇，一种在红豆杉属中发现的二萜，是在红豆杉中发现的祖克，生长在日本。尽管对紫杉醇的需求在稳步增长，但这种药物的供应是有限的。本研究旨在建立一种从栽培东北红豆杉中提取紫杉醇的方法。从这些结果来看，认为从森林资源中提取紫杉醇是可能的。从短轮伐期集约栽培的东北红豆杉幼苗等可再生资源中提取紫杉醇是日本生产紫杉醇的一种有吸引力的方法。综上所述，本研究对日本东北红豆杉中紫杉醇、浆果赤霉素III和10-去乙酰浆果赤霉素III的含量进行了检测，并开发了一种从森林资源中提取紫杉醇的有效方法。提出了利用森林资源生产紫杉醇的可能性。