Study of occurrence, proliferation and development of oral carcinomas -Exploration of abnormal cyclin-related and tumor suppresor genes-

口腔白斑的恶变过程可能需要p14ARF的低表达和P53-ARF通路的进一步异常。在口腔鳞癌中，突变型p53的表达、p14ARF的低表达、p16的缺失、Cyclin D的高表达、Rb的磷酸化、FHIT的完全缺失等与口腔鳞癌的发生、浸润和发展密切相关，骨桥蛋白与CD44结合可能产生远处转移的可能性。在涎腺肿瘤中，p53、p21、Cyclin E和D在涎腺一般上皮细胞和肌上皮细胞的增殖机制中表现出不同的趋势。鳞癌与腺癌发生于涎腺和胃部，其相关病理条件有明显的差异。在B细胞霍奇金淋巴瘤(NHL)中，P53的表达与化疗效果密切相关，可能成为判断预后的指标。以上实验结果表明，P53和Rb两条通路可能都与口腔癌的发生和增殖有关，其基础是不同的组织类型和相关条件。

Malignant-changing process of oral leukoplakia might surely demand hypoexpression of p14ARF and further abnormal occurrence of p53-ARF pathway. In case of oral SCC, it was suggested that expression of mutant p53, hypoexpression of p14ARF, p16 loss, hyperexpression of Cyclin D, phospholization of Rb, complete deficit of FHIT etc will be strongly correlated to the occurrence, infiltration and development of oral SCC.Furthermore, osteopontin might produce a possibility of distant metastasis by combination with CD44. In salivary gland tumors, it was supposed that p53, p21, Cyclin E and D showed different tendency in proliferation mechanism of general epithelia and myoepithelia of salivary gland. Between SCC and adenocarcinoma, arising from salivary gland and stomach, there were clearly guessed differences in the related pathologic conditions. In case of B-cell Hodgikin's lymphoma (NHL), p53 expression surely showed correlation between chemotherapy and its effect, resulting in becoming possible marker for prognosis.From above experimental results, both of two pathways of p53 and Rb may correlate occurrence and proliferation of oral cancers, based on different histologic types and connected conditions.