GRK 1104: From Cells to Organs: Molecular Mechanisms of Organogenesis

GRK 1104：从细胞到器官：器官发生的分子机制

• 批准号: 455540
• 金额: --
• 依托单位: Albert-Ludwigs-Universität Freiburg
• 依托单位国家: 德国
• 项目类别: Research Training Groups
• 财政年份: 2005
• 资助国家: 德国
• 起止时间: 2004-12-31 至 2013-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/455540?language=en
• 关键词: GRK; 1104; Cells; Organs; Molecular

Understanding the molecular mechanisms that control development of cells into organs is one of the key challenges of modern biomedical science, and is an essential requirement for the future application of stem cells for tissue regeneration. In the Research Training Group, basic scientists from the Biology Department of the University of Freiburg, from the Max-Planck-Institute of Immunobiology and from the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg have joint forces with biomedical scientists from the Preclinical and Clinical Departments of the Freiburg University Hospital to establish a joint research programme on organogenesis and to create an innovative training programme for graduate students interested in that field.

了解控制细胞发育成器官的分子机制是现代生物医学科学的关键挑战之一，也是未来将干细胞应用于组织再生的基本要求。在研究培训组中，来自弗赖堡大学生物系的基础科学家、来自Max-Planck免疫生物学研究所和遗传学与分子和细胞生物学研究所（IGBMC）在斯特拉斯堡，与来自弗赖堡大学医院临床前和临床部门的生物医学科学家建立了一个关于器官发生的联合研究计划，并创造了一个创新的培训。为对该领域感兴趣的研究生开设的课程。

项目成果

Transcription factor EBF1 is essential for the maintenance of B cell identity and prevention of alternative fates in committed cells

• DOI: 10.1038/ni.2641
• 发表时间: 2013-08-01
• 期刊: NATURE IMMUNOLOGY
• 影响因子: 30.5
• 作者: Nechanitzky, Robert;Akbas, Duygu;Grosschedl, Rudolf
• 通讯作者: Grosschedl, Rudolf

A thymosin beta15-like peptide promotes intersegmental myotome extension in the chicken embryo

胸腺素β15样肽促进鸡胚胎节间肌节延伸

• DOI: 10.1007/s00418-013-1156-z
• 发表时间: 2014
• 期刊: Histochemistry and Cell Biology
• 影响因子: 2.3
• 作者: Chankiewitz V;Morosan-Puopolo G;Yusuf F;Rudloff S;Pröls F;Kleff V;Hofmann DK;Brand-Saberi B
• 通讯作者: Brand-Saberi B

Copy number variation of two separate regulatory regions upstream of SOX9 causes isolated 46,XY or 46,XX disorder of sex development

• DOI: 10.1136/jmedgenet-2014-102864
• 发表时间: 2015-04-01
• 期刊: JOURNAL OF MEDICAL GENETICS
• 影响因子: 4
• 作者: Kim, Gwang-Jin;Sock, Elisabeth;Scherer, Gerd
• 通讯作者: Scherer, Gerd

Transcriptional interpretation of the EGF receptor signaling gradient

• DOI: 10.1073/pnas.1115190109
• 发表时间: 2012-01-31
• 期刊: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
• 影响因子: 11.1
• 作者: Fuchs, Alisa;Cheung, Lily S.;Pyrowolakis, George
• 通讯作者: Pyrowolakis, George

Shroom3 is required downstream of FGF signalling to mediate proneuromast assembly in zebrafish

• DOI: 10.1242/dev.083253
• 发表时间: 2012-12-15
• 期刊: DEVELOPMENT
• 影响因子: 4.6
• 作者: Ernst, Sandra;Liu, Kun;Lecaudey, Virginie
• 通讯作者: Lecaudey, Virginie