PATHOGENESIS OF KELOID WITH FOLLICULAR SEGMENTS

具有毛囊段的瘢痕疙瘩的发病机制

• 批准号: 10470377
• 负责人: OGAWA Yutaka
• 金额: $ 4.16万
• 依托单位: KANSAI MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-10470377/
• 关键词: KELOID; IMMUNUSUPPRESSER; LICHEN PILARIS; FIBROBLAST; APOTOSIS; ANTIBIOTICS; TNF α; IL6; 毛嚢培養; 抗生剤; 増殖抑制

Keloid revealed to be combined with lichen pilaris in high frequency. 62.8% of keloid patients had lichen pilaris on their arms. The other hand only 1.1% of non-keloid control showed combination of lichen pilaris. The high rate of the coexistence suggests that the hair-related disorder may be related to the etiological factor of keloid formation. The growth of human fibroblast was inhibited with various kinds of antibiotics and immunodepressant agents.The high depression group included Cefazolin, Cefalotin, Cefotiam, Flomoxef et al, the moderate depression group were piperacillin, Gentamycin and the low depression group were Vancomycin, Teichoplanin, Minomycine et.Apotosis was found more on the active part of the keloid tissue than the inactive part.IL6 was found to be promoting for the hair growth in rat experiment.Topical injection of IL6 proved the fact.

瘢痕疙瘩合并毛发苔藓的频率较高。62.8%的瘢痕疙瘩患者手臂上有毛发苔藓。而在非瘢痕疙瘩对照组中，仅有1.1%的患者出现毛发苔藓。高并存率提示毛发相关疾病可能与瘢痕疙瘩形成的病因有关。不同的抗生素和免疫抑制剂对人成纤维细胞的生长有抑制作用。高度抑制组包括头孢唑林、头孢洛汀、头孢替安、氟莫沙夫等，中度抑制组为哌拉西林、庆大霉素，低抑制组为万古霉素、替考拉宁、米诺霉素等。瘢痕疙瘩组织的活跃部分比非活跃部分有更多的细胞凋亡。白介素6在大鼠实验中被发现有促进毛发生长的作用。

项目成果

佐々木富美子: "各種抗生物質による培養ヒト線維芽細胞の増殖抑制作用の検討"日本熱傷学会誌. 26. 26-31 (2000)

Fumiko Sasaki：“各种抗生素对培养的人成纤维细胞增殖的抑制作用的研究”日本烧伤学会杂志 26. 26-31 (2000)。

K.Bessho: "Comparison of recombinant and purified human bone morphogenetic protein"British Journal of Oral and Maxillofacial Surgery. 37. 2-5 (1999)

K.Bessho：“重组和纯化的人骨形态发生蛋白的比较”英国口腔颌面外科杂志。

Kenji Kusumoto: "The Effect of Blood Supply in Muscle and an Elevated Muscle Flap on Endogenous Tissue-Engineered Bone by rhBMP-2 in the Rat"Annals of Plastic Surgery. 45・4. 409-414 (2000)

Kenji Kusumoto：“rhBMP-2 在大鼠中的肌肉血液供应和升高的肌肉瓣对内源性组织工程骨的影响”整形外科年鉴 45・4（2000）。

土井秀明: "肥厚性瘢痕と正常皮膚におけるアポトーシス"日本熱傷学会誌. 24. 195-196 (1998)

Hideaki Doi：“正常皮肤中的肥厚性疤痕和细胞凋亡”日本烧伤学会杂志 24. 195-196 (1998)。

Hideaki Doi: "Apotosis of the Fibroblast in Keloid and Hypertrophic Scar"Japanese J.Burn Injuries. 24-4. 195-196 (1998)

Hideaki Doi：“瘢痕疙瘩和肥厚性疤痕中成纤维细胞的凋亡”日本 J.烧伤损伤。