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Histopathological Study for the Development of Adhesive Resin Systems with a Calcification Promoting Function as a Direct Pulp Capping Agent

开发具有钙化促进功能的粘合树脂系统作为直接盖髓剂的组织病理学研究

基本信息

批准号：
10470409
负责人：
KATOH Yoshiroh
金额：
$ 2.94万
依托单位：
Nippon Dental University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1998
资助国家：
日本
起止时间：
1998 至 2000
项目状态：
已结题

项目摘要

The results of a histopathological study of direct pulp capping in Macaca fascicularis suggested that adhesive resins caused no irritation to the pulp tissue or if so, it was extremely low and differences were found among the materials. When the pulp was protected and safely covered by direct capping using appropriate selected adhesive resins. New dentin formed on the exposed surface of the pulp and it should extend to the complete dentin bridge in the maturation process over time. It was also suggested that no inorganic cement was necessary as the material of the sub-base and base after Ca(OH)_2 hybridization with adhesive resin. Concerning the irrigation effect of dentinal chips between the alternate cleansing agents of 3%H_2O_2-6%NaOCl and 7%H_2O_2-10%NaOCl, higher concentrations of the agents did not always show better cleansing effect or wound healing properties of the pulp. Regarding the laser irradiation effect on the exposed pulp surface, no wound healing effect was actively re … More cognized of irradiation conditions used in this experiment. With the assistance of two manufactures, a histopathological study for the development of adhesive resin systems with a calcification promoting function as a direct pulp capping agent was examined. To summarize, the following experimentally developed materials : PR2B and PR2 groups in the Phenyl-P system and polymers containing 3%, 5% and 10% Ca(OH)_2 in the 4-META/MMA-TBB system showed a high possibility to be used as direct pulp capping agents. With the consent of the patients, the long-term clinical prognosis of the pulp directly or indirectly capped with adhesive resins on accidentally exposed pulp or pink spots found on the pulpal wall in deeply prepared cavities during conservative treatment was investigated. In total, seventeen teeth of 15 patients were capped directly and the remaining one was capped indirectly. The exposed size of the pulp was approximately 0.7mm in average. Long-term clinical prognosis, approximate 4 years in average of sixteen teeth of 13 patients (88.9%) was extremely good. Devitalization of the pulp with pulp necrosis was observed in two teeth of 2 patients (11.1%). The long-term clinical results clearly supported the results obtained in the previous studies. Namely, the results suggested that adhesive resins caused extremely low irritation to the pulp tissue. But differences between the materials were found.To conclude, it was clearly confirmed that adhesive resin is an appropriate material for use in certain cases as a direct pulp capping agent in clinic. At the same time, further investigation on both pulp diagnosis and the restorative pattern of teeth will be required. Less

对猕猴直接盖髓的组织病理学研究结果表明，粘接树脂对牙髓组织没有刺激作用，即使有刺激作用，也极低，不同材料之间存在差异。当牙髓被保护和安全覆盖时，使用适当选择的粘接树脂直接封盖。新的牙本质在牙髓暴露的表面形成，随着时间的推移，它应该延伸到完整的牙本质桥。Ca(OH)_2与粘接树脂杂交后，不需要无机水泥作为亚基和碱基的材料。对比3%H_2O_2-6%NaOCl和7%H_2O_2-10%NaOCl两种洗洁剂对牙本质切屑的冲洗效果，结果表明，浓度越高的洗洁剂对牙髓的清洁效果和伤口愈合效果不一定越好。对于暴露牙髓表面的激光照射效果，没有明显的创面愈合效果。在两家制造商的帮助下，对具有促进钙化功能的粘连树脂系统的开发进行了组织病理学研究，作为一种直接的牙髓封盖剂进行了研究。综上所述，实验开发的材料：苯基- p体系中的PR2B和PR2基团以及4-META/MMA-TBB体系中Ca(OH)_2含量分别为3%、5%和10%的聚合物均有可能作为直接封浆剂。在患者同意的情况下，对保守治疗中意外暴露的牙髓或深度预备腔内牙髓壁上发现的粉红色斑点直接或间接用粘接剂覆盖牙髓的长期临床预后进行了研究。15例患者共17颗牙直接盖牙，1颗牙间接盖牙。牙髓暴露尺寸平均约0.7mm。长期临床预后，平均约4年16颗牙13例（88.9%）预后极好。2例（11.1%）患者出现牙髓失活伴牙髓坏死。长期临床结果明显支持以往研究的结果。也就是说，结果表明粘接树脂对牙髓组织的刺激极低。但发现了材料之间的差异。综上所述，粘连树脂在临床上作为直接盖髓剂在某些情况下是一种合适的材料。同时，对牙髓的诊断和牙齿的修复模式还需要进一步的研究。少