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Studies of effect of air pollutions on allergic rhinitis and conjunctivitis and their mechanisms

空气污染对过敏性鼻炎、结膜炎的影响及其机制研究

基本信息

批准号：
11470116
负责人：
KOBAYASHI Takahiro
金额：
$ 9.15万
依托单位：
National Institute for Environmental Studies
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1999
资助国家：
日本
起止时间：
1999 至 2002
项目状态：
已结题

项目摘要

This project designed to elucidate the effects of exposure to diesel exhaust NO2 or O3 on allergic pollenosis ,such as nasal allergy, and allergic conjunctivitis induced by repeated antigen administration, the lowest observed adverse effect level, and the mechanisms. Effects of DE containing 0.1. 0.3, 1.0 mg/m3 particles on nasal allergy, and allergic conjunctivitis are investigated using indices such as sneezes, nasal secretion, score of the symptoms of conjunctivitis, vascular permeability, OA specific IgG and IgE titer, infiltration of eosinophils in epithelium and subepithelium of nasal mucosa and conjunctiva, and responsiveness to physical stimuli or histamine. Exposure to DE enhances nasal and conjunctival allergic resposes, OA specific IgG and IgE titer, infiltration of eosinophils, responsiveness to histamine dose dependent manner. The lowest observed adverse effect level is DE containing 0.1 mg/m3-particles. Effects of 0.1, 0.3, 1.0, 3.0, 10 ppm NO2 on nasal allergy, and allergic conjunctivitis are investigated using same indices used in DE. Exposure to NO2 enhances nasal and conjunctival allergic resposes, infiltration of eosinophils, dose dependent manner. The lowest observed adverse effect level of NO2 is 1 ppm. Effects of 0.1 0.2. 0.4, 0.6 ppm 03 on nasal allergy, and allergic conjunctivitis are investigated using same indices used in DE. Exposure to O3 enhances nasal and conjunctiva! allergic resposes, OA specific IgG titer, infiltration of eosinophils, responsiveness to physical stimuli dose dependent manner. The lowest observed adverse effect level of03 is 0.4 ppm.

本项目旨在阐明暴露于柴油废气NO2或O3对过敏性花粉症（如鼻腔过敏、反复给抗原引起的过敏性结膜炎）的影响、观察到的最低不良反应水平及其机制。含DE 0.1的效果。通过打喷嚏、鼻分泌物、结膜炎症状评分、血管通透性、OA特异性IgG和IgE滴度、鼻黏膜和结膜上皮和上皮下嗜酸性粒细胞的浸润、对物理刺激或组胺的反应性等指标，研究0.3、1.0 mg/m3颗粒对鼻过敏和过敏性结膜炎的影响。暴露于DE增强鼻和结膜过敏反应，OA特异性IgG和IgE滴度，嗜酸性粒细胞浸润，组胺反应剂量依赖性。观察到的最低不良影响水平是含有0.1 mg/m3颗粒的DE。采用与DE相同的指标，研究了0.1、0.3、1.0、3.0、10 ppm NO2对鼻变态反应和过敏性结膜炎的影响。NO2暴露可增强鼻和结膜变态反应、嗜酸性粒细胞的浸润，并呈剂量依赖性。NO2的最低不良影响水平为1ppm。效应0.1 0.2。使用与DE相同的指标研究了0.4,0.6 ppm 03对鼻过敏和过敏性结膜炎的影响。暴露于O3会增强鼻和结膜！过敏反应，OA特异性IgG滴度，嗜酸性粒细胞浸润，对物理刺激的反应剂量依赖性。观察到的最低不良影响水平为0.4 ppm。