Mechanisms of graft sclerosis by advanced glycation end product deposition - With the aim of elucidation of arteriosclerosis and development of therapy for arteriosclerosis

目的：内侧弹性薄片可作为动脉粥样硬化危险因素的屏障：晚期糖基化终产物（AGE）可导致糖尿病患者动脉的蛋壳钙化。本研究评估了AGE在胸内动脉内侧弹性板中的沉积。材料与方法选取尸检时无动脉硬化和糖尿病的男性13例，女性3例，年龄15 ~ 79岁。应用自体荧光检测法研究AGE在胸内动脉中的沉积。采用形态测量法测定胸内动脉内侧弹性板厚度和数量。结果16具尸体胸内动脉均有AGE沉积。AGE在胸内动脉的沉积程度随着年龄的增长而增加。随着年龄的增长，胸内动脉内侧厚度增加，胸内动脉弹性层数减少。结论随着年龄的增长，AGE的沉积可能降低了内侧弹性层对动脉粥样硬化的防御机制。

Purpose Medial elastic lamellae works as a barrier against atherosclerotic risk factors: Advanced glycation end product (AGE) causes egg shell calcification in arteries of diabetic patients. This study assessed AGE deposition in medial elastic lamellae of internal thoracic arteries.Materials and Methods Internal thoracic arteries were obtained from 13 males and 3 females (aged 15-79 years) who did not suffer from arteriosclerosis and diabes at autopsy. AGE deposition in internal thoracic arteries was studied by autofluorescence detection method. Medial thickness and number of medial elastic lamellae of internal thoracic arteries were measured by morphometry. Results AGE deposition was detected in all internal thoracic arteries of 16 cadavers. Degree of AGE deposition in internal thoracic arteries was increased with aging. Medial thickness of internal thoracic arteries also increased with aging, while number of elastic lamellae of internal thoracic arteries decreased.Conclusion Defense mechanism of medial elastic lamellae against atherosclerosis may reduce due to AGE deposition with aging.