Mechanisms of graft sclerosis by advanced glycation end product deposition - With the aim of elucidation of arteriosclerosis and development of therapy for arteriosclerosis

晚期糖基化终产物沉积导致移植物硬化的机制 - 旨在阐明动脉硬化并开发动脉硬化疗法

• 批准号: 11470236
• 负责人: SASAJIMA Tadahiro
• 金额: $ 9.66万
• 依托单位: Asahikawa Medical College
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11470236/
• 关键词: advanced glycation end product; graft sclerosis; arteriosclerosis; medial elastic lamella; vascular smooth muscle cell; apoptosis; advanced glycation end product

Purpose Medial elastic lamellae works as a barrier against atherosclerotic risk factors: Advanced glycation end product (AGE) causes egg shell calcification in arteries of diabetic patients. This study assessed AGE deposition in medial elastic lamellae of internal thoracic arteries.Materials and Methods Internal thoracic arteries were obtained from 13 males and 3 females (aged 15-79 years) who did not suffer from arteriosclerosis and diabes at autopsy. AGE deposition in internal thoracic arteries was studied by autofluorescence detection method. Medial thickness and number of medial elastic lamellae of internal thoracic arteries were measured by morphometry. Results AGE deposition was detected in all internal thoracic arteries of 16 cadavers. Degree of AGE deposition in internal thoracic arteries was increased with aging. Medial thickness of internal thoracic arteries also increased with aging, while number of elastic lamellae of internal thoracic arteries decreased.Conclusion Defense mechanism of medial elastic lamellae against atherosclerosis may reduce due to AGE deposition with aging.

目的内侧弹力膜作为动脉粥样硬化危险因素的屏障：晚期糖基化终产物（AGE）可导致糖尿病患者动脉蛋壳样钙化。材料与方法取15-79岁无动脉硬化、无糖尿病的正常人胸廓内动脉，男13例，女3例。用自体荧光检测法研究了胸廓内动脉中AGE的沉积。应用形态计量学方法测量胸廓内动脉内侧弹性膜的厚度和数目。结果16例标本的胸廓内动脉均有AGE沉积。胸廓内动脉AGE沉积程度随增龄而增加。结论随着年龄的增长，血管内膜弹性膜对动脉粥样硬化的防御机制可能由于AGE的沉积而减弱。