ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLIC

人糖蛋白PC-1密码子Q121等位基因与胰岛素抵抗相关，但与2型糖尿病或肥胖无关。我们调查了PC-1 Q121在多米尼加共和国人群中的患病率（研究了755名受试者），以及该变体是否与胰岛素抵抗、肥胖或2型糖尿病相关。与其他人群相比，PC-1 Q121的患病率较高。基因型检出率分别为KK 21.6%、KQ 48.3%、QQ 30.1%。相比之下，其他人群的这一比例分别为74%、24%和22%。在非肥胖、非糖尿病受试者中，KQ（Pz0.027）和QQ（Pz0.031）受试者在口服葡萄糖耐量试验期间的胰岛素反应大于KK受试者，而血浆葡萄糖曲线则大于KK受试者。可比性Q等位基因在肥胖2型糖尿病患者中的频率高于对照组（Th0.026，0R1.56）。校正年龄、性别和BMI后的多元回归分析显示，QQ基因型与2型糖尿病相关（Pz0.043，0R2.74），而与肥胖无关（P0.068）。这些结果表明，PC-1 Q121等位基因在多米尼加共和国异常普遍，导致胰岛素抵抗和2型糖尿病。

The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin resistance, but not with type 2 diabetes or obesity. We investigated the prevalence of PC-1 Q121 in the Dominican Republic population (755 subjects studied), and whether this variant is associated with insulin resistance, obesity or type 2 diabetes. The prevalence of PC-1 Q121 was high compared to other populations. The proportions of genotypes detected were KK 21.6%, KQ 48.3%, and QQ 30.1%. This compares to 〜74%, 〜24% and 〜2% in other populations. Among non-obese, non-diabetic subjects, the insulin response of KQ (Pz0.027) and QQ (Pz0.031) subjects was greater during the oral glucose tolerance test than the KK subjects, while plasma glucose profiles were. comparable. The Q allele was more prevalent in obese type 2 diabetics than in controls (Th0.026, 0R1.56). Multiple regression analysis after adjusting for age, gender and BMI showed the QQ genotype was associated with type 2 diabetes (Pz0.043, 0R2.74) but not obesity (P0.068). These results indicate that the PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic, contributing to both insulin resistance and type 2 diabetes.