ANALYSIS OF THE SUSCEPTIBILITY GENES FOR OBESE DIABETES IN THE DOMINICAN REPUBLIC

多米尼加共和国肥胖型糖尿病易感基因分析

• 批准号: 13576024
• 负责人: YOSHIMATSU Hironobu
• 金额: $ 7.1万
• 依托单位: OITA MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13576024/
• 关键词: Dominican Republic; diabetes mellitus; obesity; genetic analysis; insulin resistance; PC-1; 多型; 生活習慣病; SNP; 糖尿病; 疫学; 高脂血症; 遺伝子多型

The human glycoprotein PC-1 codon Q121 allele has been correlated with insulin resistance, but not with type 2 diabetes or obesity. We investigated the prevalence of PC-1 Q121 in the Dominican Republic population (755 subjects studied), and whether this variant is associated with insulin resistance, obesity or type 2 diabetes. The prevalence of PC-1 Q121 was high compared to other populations. The proportions of genotypes detected were KK 21.6%, KQ 48.3%, and QQ 30.1%. This compares to 〜74%, 〜24% and 〜2% in other populations. Among non-obese, non-diabetic subjects, the insulin response of KQ (Pz0.027) and QQ (Pz0.031) subjects was greater during the oral glucose tolerance test than the KK subjects, while plasma glucose profiles were. comparable. The Q allele was more prevalent in obese type 2 diabetics than in controls (Th0.026, 0R1.56). Multiple regression analysis after adjusting for age, gender and BMI showed the QQ genotype was associated with type 2 diabetes (Pz0.043, 0R2.74) but not obesity (P0.068). These results indicate that the PC-1 Q121 allele is exceptionally prevalent in the Dominican Republic, contributing to both insulin resistance and type 2 diabetes.

人类糖蛋白 PC-1 密码子 Q121 等位基因与胰岛素抵抗相关，但与 2 型糖尿病或肥胖无关。我们调查了多米尼加共和国人群（研究了 755 名受试者）中 PC-1 Q121 的患病率，以及该变异是否与胰岛素抵抗、肥胖或 2 型糖尿病相关。与其他人群相比，PC-1 Q121 的患病率较高。检测到的基因型比例为KK 21.6%、KQ 48.3%、QQ 30.1%。相比之下，其他人群的这一比例为〜74%、〜24% 和〜2%。在非肥胖、非糖尿病受试者中，口服葡萄糖耐量试验期间 KQ (Pz0.027) 和 QQ (Pz0.031) 受试者的胰岛素反应高于 KK 受试者，而血浆葡萄糖谱也高于 KK 受试者。可比。 Q 等位基因在肥胖 2 型糖尿病患者中比对照组更常见（Th0.026、0R1.56）。调整年龄、性别和BMI后的多元回归分析显示，QQ基因型与2型糖尿病相关（Pz0.043，0R2.74），但与肥胖无关（P0.068）。这些结果表明 PC-1 Q121 等位基因在多米尼加共和国异常普遍，导致胰岛素抵抗和 2 型糖尿病。

项目成果

Hidaka S, Yoshimatsu H, Koridou S, Oka K, Tsuruta Y, Sakino H, Itateyama B, Noguchi H, Himeno K, Okamoto K, Teshima Y, Okeda T, Sakata T.: "Hypoleptinemia, but not hypoinsulinemia, induces hyperphagia in streptozotocin-induced diabetic rats"J Neurochem. 7

Hidaka S, Yoshimatsu H, Koridou S, Oka K, Tsuruta Y, Sakino H, Itateyama B, Noguchi H, Himeno K, Okamoto K, Teshima Y, Okeda T, Sakata T.：“低肽素血症，而不是低胰岛素血症，会引起食欲亢进。

Yoshimichi G, et al.: "Orexin-A regulates body temperature in coordination with arousal status"Exp Biol Med. 226. 468-476 (2001)

Yoshimichi G 等人：“Orexin-A 与唤醒状态协调调节体温”Exp Biol Med。

Katsuragi I, et al.: "Transplantation of normal islets into the portal vein of Otsuka Long Evans Tokushima Fatty rats prevents diabetic progression"Exp Biol Med. 226. 681-685 (2001)

Katsuragi I 等人：“将正常胰岛移植到 Otsuka Long Evans Tokushima 肥胖大鼠的门静脉中可预防糖尿病进展”Exp Biol Med。

Yoshimichi G, Yoshimatsu H, Masaki T, Sakata T.: "Orexin-A regulates body temperature in coordination with arousal status"Exp Biol Med. 226. 438-476 (2001)

Yoshimichi G、Yoshimatsu H、Masaki T、Sakata T.：“Orexin-A 与唤醒状态协调调节体温”Exp Biol Med。

Yoshimatsu H, et al.: "Histidine induces lipolysis through sympathetic nerve in white adipose tissue"Eur J Clin Invest. 32. 236-241 (2002)

Yoshimatsu H 等人：“组氨酸通过白色脂肪组织中的交感神经诱导脂肪分解”Eur J Clin Invest。