Study on biological mechanism, specially, information transmittance by malting use of high resolution spectroscopic method

利用高分辨率光谱法研究麦芽的生物机制，特别是信息传递

• 批准号: 14340177
• 负责人: OHASHI Nobukimi
• 金额: $ 9.6万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14340177/
• 关键词: peptide molecules; large amplitude vibration; internal rotation; microwave spectrum; Fourier transform spectrum; two-top molecules; three-top molecules; 純回転スペクトル; マイクロ波スペクトル; 回転スペクトル; フーリェ変換スペクトル

In the present project, a nozzle-jet Fourier transform microwave (ETTMW) spectrometer was newly constructed in Kanazawa University, and the FTMW existing already in Kanagawa Institute of Technology was revised. Using these two FTMW spectrometers, and also using the instrument in National Institute of Standards and Technology (NIST) of U.S,A. through collaborative work, pure rotational spectra of peptide molecules and other molecular species involving large-amplitude motions were investigated to obtain information on intra-moleculaar interactions useful for understanding mechanism of biological information transmittance. Molecular species studied in the present project are dimethyl methylphosphonate, N-methylpropionamide, N-methylformamide, N-methylacetamide, 1,1-dimethylsilacyclobutane, N-methylaniline, N,N-dimethylacetamide, Ar-dimethyl ether complex, Ne-dimethyl ether complex etc. For examples, a transition probability relating to transmittanee of the three CH_3-internal rotations occurring through Coriolis interaction between overall-rotation and internal-rotation was obtained for the N,N-dimethylacetamide, and a contribution to a rotational constant of the interaction between CH_3-internal rotation and ring-puckering motion was determined for the 1,1-dimethylsilacyclobutane molecule. Information involved in these quantities is useful, which are considered to be strongly related to information transmittance of fiologically related molecules.

在本项目中，金泽大学新建造了一台射流傅里叶变换微波（ETTMW）光谱仪，并对神奈川工业大学现有的FTMW进行了修订。利用这两台FTMW光谱仪，并利用美国国家标准技术研究所（NIST）的仪器，对样品进行了红外光谱分析。通过协同工作，研究了肽分子和其他涉及大幅度运动的分子物种的纯转动光谱，以获得有助于理解生物信息传递机制的分子内相互作用的信息。本项目研究的分子物种有甲基膦酸二甲酯、N-甲基丙酰胺、N-甲基甲酰胺、N-甲基乙酰胺、1，1-二甲基硅环丁烷、N-甲基苯胺、N，N-二甲基乙酰胺、Ar-二甲醚络合物、Ne-二甲醚络合物等。通过整体转动和内转动之间的Coriolis相互作用，得到了与三个CH_3-内转动传递有关的跃迁几率。测定了N，N-二甲基乙酰胺分子的转动常数和1，1-二甲基硅环丁烷分子的CH_3-内转动与皱环运动相互作用对转动常数的贡献。这些量中所涉及的信息是有用的，其被认为与纤维学相关分子的信息透射率密切相关。

项目成果

Fourier transform microwave spectroscopy of 1,1-dimethylsilacyclobutane. Interplay of two types of large amplitude motions : two-top internal rotation and ring puckering

1,1-二甲基硅杂环丁烷的傅里叶变换微波光谱。

• 发表时间: 2004
• 期刊: Journal of Molecular Spectroscopy 228
• 作者: 廣田榮冶;大橋信喜美;川嶋良章;宇佐美豪士
• 通讯作者: 宇佐美豪士

Fourier transform microwave spectra and ab initio calculation of N-ethylformamide

N-乙基甲酰胺的傅里叶变换微波谱及从头算

• 发表时间: 2005
• 期刊: Journal of Molecular Structure (印刷中)
• 作者: 大場恵介;宇佐美豪士;川嶋良章;廣田榮冶
• 通讯作者: 廣田榮冶

Analysis and fit of the Fourier-transform mocrowave spectrum of the two-top molecule N-methylacetamide

二顶分子N-甲基乙酰胺的傅里叶变换微波谱分析与拟合

• 发表时间: 2004
• 期刊: Journal of Molecular Spectroscopy 227
• 作者: 大橋信喜美;J.T.Hougen;R.D.Suenram;F.J.Lovas;川嶋良章;藤竹正晴;J.Pyka
• 通讯作者: J.Pyka

Line assignments and global analysis of the tunneling-rotational microwave absorption spectrum of dimethyl methylphosphonate

甲基膦酸二甲酯隧道旋转微波吸收谱的谱线分配和全局分析

• 发表时间: 2003
• 期刊: Journal of Molecular Spectroscopy 218
• 作者: 大橋信喜美;J.Pyka;G.Yu.Golubiatnikov;J.T.Hougen;R.D.Suenram;F.J.Lovas;A.Lesarri;川嶋良章
• 通讯作者: 川嶋良章

川嶋良章, R.D.Suenram, 廣田榮治: "Dynamical structure of peptide molecules: Fourier transform microwave spectroscopy of N-methylpropionamide"Journal of Molecular Spectroscopy. (印刷中). (2003)

Yoshiaki Kawashima、R.D.Suenram、Eiji Hirota：“肽分子的动态结构：N-甲基丙酰胺的傅里叶变换微波光谱”分子光谱学杂志（2003 年）。