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The development of an ESR NMR hybrid imaging system for observation of free radicals in biological systems

用于观察生物系统中自由基的 ESR NMR 混合成像系统的开发

基本信息

批准号：
14370282
负责人：
TSUCHIHASHI Nobuaki
金额：
$ 8.83万
依托单位：
Fukushima Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14370282/
关键词：
ESR NMR free radical imaging spin echo 2D FFT CW pulse 磁場勾配 CW-NMR パルスNMR FID信号

项目摘要

The aim of this study is development of an ESR/NMR hybrid imaging system, where one can obtain ESR image (free radical imaging) and NMR images (anatomical imaging) of a sample without moving the sample. First, an ESR/NMR resonator was fabricated. It consisted of an ESR resonator, a bridged loop-gap resonator (730 MHz), and an NMR resonator, an LC circuit (27 MHz) of a solenoid coil and variable capacitor. The former was located inside the latter. By using the ESR/NMR resonator, CW-ESR, CW-NMR, and pulsed NMR measurements of a phantom could be made. Second, field gradient coils for NMR imaging were fabricated. To apply pulse-shaped field gradients to a sample in a shield case, field gradient coils must be located in the case, so four-layered electric board including 3 gradient coils and shield that could be used for side wall of the shield case was fabricated. By using the ESR/NMR resonator, the NMR gradient coils and main electromagnet for ESR, NMR imaging (spin echo and 2D FFT) of the phantom and mice was performed. Because of inhomogenous and unstable field caused by the ESR main magnet, the images obtained showed inhomogenous intensity and distortion. To overcome this problem, development of NMR main coil that can be switch to lower field for ESR measurement will be needed.

本研究的目的是开发一种ESR/NMR混合成像系统，在该系统中，可以在不移动样品的情况下获得样品的ESR图像（自由基成像）和NMR图像（解剖成像）。首先，制作了ESR/NMR谐振器。它包括一个ESR谐振器，一个桥接环隙谐振器（730 MHz），和一个NMR谐振器，一个LC电路（27 MHz）的螺线管线圈和可变电容器。前者位于后者的内部。通过使用ESR/NMR共振器，可以进行体模的CW-ESR、CW-NMR和脉冲NMR测量。其次，制作了用于核磁共振成像的场梯度线圈。为了向屏蔽罩中的样品施加脉冲形状的场梯度，场梯度线圈必须位于屏蔽罩中，因此制作了包括3个梯度线圈和屏蔽罩的四层电板，其可以用于屏蔽罩的侧壁。通过使用ESR/NMR共振器、NMR梯度线圈和用于ESR的主电磁铁，对体模和小鼠进行NMR成像（自旋回波和2D FFT）。由于ESR主磁体引起的磁场不均匀和不稳定，所获得的图像显示强度不均匀和失真。为了克服这个问题，将需要开发可以切换到较低场用于ESR测量的NMR主线圈。