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^1H-MRS study on age differences in intramuscular lipids in human skeletal muscle and their relation to body composition and blood component

^1H-MRS研究人类骨骼肌肌内脂质的年龄差异及其与身体成分和血液成分的关系

基本信息

批准号：
14380003
负责人：
NAKAGAWA Yoshinao
金额：
$ 6.98万
依托单位：
Otaru University of Commerce
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

In this study we looked at changes with age in intramyocellular lipid (IMCL) and extramyocellular lipid (EMCL) concentrations in skeletal muscles using ^1H-MR spectroscopy and studied their relation to % body fat, W/H ratio, and blood components. Forty-seven subjects with an age range of 20-74 yrs and a body mass index (BMI) of <25kg/m^2 took part in the study. Subjects were grouped by gender into age- and BMI-matched young and old groups. IMCL and EMCL content in SOL and MG in the old was found to be higher (p<0.01) than that in young. Therefore, total lipids in SOL (soleus muscle) and MG (medial gastrocnemius muscle) were also markedly higher in the old. However, no difference was found in IMCL or EMCL content with age in TA (tibialis anterior muscle). In terms of EMCL/IMCL ratio, a difference was found in TA and MG with age. No correlation was found between intramuscular lipid content (both for IMCL and EMCL) in each muscle and BMI. However, IMCL and EMCL contents correlated significantly with waist-hip ratio (WHR) in all skeletal muscles. Moreover, a significant relationship was observed between % body fat and IMCL in TA and MG (p<0.05). IMCL and EMCL content in all skeletal muscle significantly correlated to HbA1c,TG,TC,LDL-C concentrations. These results suggest that an age-related increase in intramyocellular lipid on might be related to body composition, blood lipids and lipoprotein profiles, and that this might affect health risks and muscle attenuation with age in lean elderly persons.

在这项研究中，我们使用^1H-MR波谱观察了骨骼肌中肌细胞内脂质（IMCL）和肌细胞外脂质（EMCL）浓度随年龄的变化，并研究了它们与体脂百分比、W/H比和血液成分的关系。47名年龄在20-74岁之间，体重指数（BMI）<25 kg/m^2的受试者参加了这项研究。受试者按性别分为年龄和BMI匹配的年轻组和老年组。老年人SOL和MG中IMCL和EMCL含量均高于青年人（P<0.01）。因此，SOL（比目鱼肌）和MG（内侧腓肠肌）的总脂质也显着高于老年人。而胫前肌中IMCL和EMCL含量随年龄变化无显著性差异。在EMCL/IMCL比值方面，TA和MG随年龄的增加而存在差异。在每块肌肉的肌内脂质含量（IMCL和EMCL）和BMI之间没有发现相关性。而IMCL和EMCL含量与腰臀比（WHR）呈显著正相关。此外，在TA和MG中观察到%体脂与IMCL之间的显著相关性（p<0.05）。各骨骼肌IMCL和EMCL含量与HbA 1c、TG、TC、LDL-C呈显著相关。这些结果表明，与年龄相关的肌细胞内脂质的增加可能与身体成分，血脂和脂蛋白谱，这可能会影响健康风险和肌肉衰减随着年龄的瘦老年人。