Method for analyzing of dynamic cerebral autoregulation, and its significance : Comparable study and dynamic and static cerebral autoregulation on autoregulation curve.

动态脑自动调节分析方法及其意义：动态与静态脑自动调节曲线的比较研究。

• 批准号: 15390544
• 负责人: ENDOH Hiroshi
• 金额: $ 3.71万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15390544/
• 关键词: Dynamic Cerebral autoregulation; Static Cerebral autoregulation; Autoregualtion Curve; Transfer function; Frequency domain; coherence; Gain; Phase; クロススペクトル解析; 動的脳自動調節機能; システム同定

1.Data Acquisition :Arterial pressure, blood flow velocity in the middle cerebral artery(Vmca) measured with transcranial Doppler(TCD), and ECG were simultaneously recorded into PC via AD converter in 5 adult volunteers.2.Development of new method for analyzing of dynamic cerebral autoregulation(dCAR) :Beat by beat mean values of arterial pressure (MAP) and Vmca were calculated, aligned at each R peak of ECG, and then resampled at 0.5Hz. dCAR was analyzed with using transfer function between MAP and mean Vmca. V Coherence (coh), gain, and phase were calculated. During hypercpnia (PetCO_2>50mmHg), coh <0.07Hz was significantly increased, and normalized during normocapnia ((PetCO_2:30-40mmHg). These results indicate that an increase of coh <0.07Hz may be reliable indicator of dCAR.3.Evaluation of dCAR on static autoregulation curve :(1)Animal study : Regional CBF(rCBF) measured with laser Doppler, Vmca measured with TCD,ECG,and MAP were simultaneously measured in 5 adult cats. Stepwise changes of MAP(40,70,100,120,and 180mmHg) were induced by phlebotomy, transfusion, or an infusion of phenylephrine. Steady condition was maintained at each MAP for 5min, and dCAR was evaluated at each MAP. Normocapnia was maintained during study.(2)Results :mean Vmca and rCBF were maintained in the range of MAP between 70-120mmHg, and significantly reduced at MAP of 40mmHg, and increased at MAP of 180mmHg(P<0.05 in both). As compared at 100mmHg, coh in <0.07Hz was significantly increased at MAP=40mmHg, and coh in all frequency was significantly increased at MAP=180mmHg (P<0.05 in both).4.Conclusion :An increase of coh <07Hz can clearly correlate with degree of impairment of static autoregulation. Thus, bed side evaluation of dCAR is feasible and reliable.

1.数据采集：5名成年志愿者的动脉压、经颅多普勒（TCD）测量的大脑中动脉（Vmca）血流速度（Vmca）以及心电图通过AD转换器同时记录到PC中。2.动态脑自动调节（dCAR）分析新方法的开发：逐次心跳的动脉压（MAP）和心电图平均值 计算 Vmca，在 ECG 的每个 R 峰值处对齐，然后以 0.5Hz 重新采样。使用 MAP 和平均 Vmca 之间的传递函数分析 dCAR。计算 V 相干性 (coh)、增益和相位。在高碳酸血症期间（PetCO_2>50mmHg），coh <0.07Hz 显着增加，并在正常碳酸血症期间正常化（（PetCO_2：30-40mmHg）。这些结果表明，coh <0.07Hz 的增加可能是 dCAR 的可靠指标。3.静态自动调节曲线上 dCAR 的评估：（1）动物研究：区域 CBF（rCBF） 激光多普勒测量、TCD测量Vmca、心电图、MAP同时测量5只成年猫。通过放血、输血或输注去氧肾上腺素诱导 MAP 逐步变化（40、70、100、120 和 180mmHg）。在每个 MAP 下维持稳定状态 5 分钟，并在每个 MAP 下评估 dCAR。正常碳酸血症 (2)结果:平均Vmca和rCBF维持在MAP 70-120mmHg范围内,在MAP 40mmHg时显着降低,在MAP 180mmHg时升高(均P<0.05)。与100mmHg相比，MAP=40mmHg时<0.07Hz的coh显着增加，MAP=180mmHg时所有频率的coh显着增加 (两者P<0.05)。4.结论：coh<07Hz的增加与静态自动调节受损程度明显相关。因此，dCAR的床边评估是可行且可靠的。

项目成果

Lung injury induced by mechanical ventilation

机械通气引起的肺损伤

• 发表时间: 2005
• 期刊: Journal of Medical association of Niigata City 409
• 作者: Araki Y;Endoh H
• 通讯作者: Endoh H

肥田 誠治: "急性肺傷害に対するエラスターゼ阻害薬の使用経験"日本集中治療医学会誌. 10. 373-374 (2003)

Seiji Hida：“使用弹性蛋白酶抑制剂治疗急性肺损伤的经验”日本重症监护医学会杂志 10. 373-374 (2003)。

心臓大血管術後の呼吸不全に対する腹臥位人工呼吸の効果

俯卧位机械通气对心血管术后呼吸衰竭的影响

• 发表时间: 2005
• 期刊: 日本集中治療医学会雑誌 12(1)
• 作者: Akita S;Fukui M;Nakagawa H;Fujii T;Akino K;葉山 文恵;秋田定伯;福地 健郎;八百枝 潔;Atsushi Fukushima;Chihiro Mayama;Tomoko Nakatsue;Masaaki Seki;Tomoyo Funayama;白柏 基宏;白柏 基宏;阿部 春樹;八百枝 潔;大橋 さとみ;大橋 さとみ
• 通讯作者: 大橋 さとみ

腎膿瘍術後に全身炎症反応症候群に伴う急性肺傷害を発症した1例

肾脓肿术后并发全身炎症反应综合征急性肺损伤1例

• 发表时间: 2003
• 期刊: Progress in Medicine 23
• 作者: 肥田 誠治

ダイナミックメディシン

动态医学

• 发表时间: 2003
• 作者: Matsuzawa;A. et al.;遠藤 裕
• 通讯作者: 遠藤 裕