Computer simulation of DNA biochips

DNA生物芯片的计算机模拟

• 批准号: DP0558938
• 负责人: Dr Stefano Piana
• 金额: $ 17.15万
• 依托单位: Curtin University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-03-01 至 2007-08-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558938
• 关键词: Computer; simulation; DNA; biochips

The DNA biochip technology has been a major breakthrough in cell biology and clinical analysis. Companies in Australia and in the rest of the world are now developing biochips for genome sequencing and point-of-care diagnosis. DNA biochips have the potential to provide simple, fast and accurate clinical analysis, thus enhancing the efficiency of medical treatments and reducing the costs of health care. The structural properties of the immobilized DNA are critical for determining the DNA chip sensitivity and efficiency. A fundamental understanding of the molecular interactions at the surface of a biochip is therefore not only relevant for the scientific community, but can have direct implications for the design of improved DNA chips.

DNA生物芯片技术是细胞生物学和临床分析领域的重大突破。澳大利亚和世界其他地区的公司现在正在开发用于基因组测序和即时诊断的生物芯片。DNA生物芯片有可能提供简单、快速和准确的临床分析，从而提高医疗效率并降低保健成本。 固定化DNA的结构性质对于决定DNA芯片的灵敏度和效率至关重要。因此，对生物芯片表面分子相互作用的基本理解不仅与科学界有关，而且对改进DNA芯片的设计有直接影响。