Do depolarizing currents in the endothelium evoke contraction of vascular smooth muscle?

内皮细胞的去极化电流会引起血管平滑肌的收缩吗？

• 批准号: DP0558943
• 负责人: Em/Prof Helena Parkington
• 金额: $ 21.46万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2005
• 资助国家: 澳大利亚
• 起止时间: 2005-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP0558943
• 关键词: Do; depolarizing; currents; endothelium; evoke

Establishment of our concept involving a novel constricting influence in blood vessels will have two major benefits. First, it will keep Australian research at the leading edge in blood vessel research and thus maintain a very high international profile for Australian science. Second, our concept represents a whole new field of therapeutic potential for treating a range of vascular diseases involving excessive constriction of blood vessels. The development and manufacture of drugs in Australia would contribute to the national economy, and their consumption could improve the quality of life for those suffering from vascular diseases amenable to treatment by such drugs, likely to include pre-eclampsia, diabetes, hypertension.

建立涉及血管新的收缩影响的概念将有两个主要好处。首先，它将使澳大利亚研究保持在血管研究领域的领先地位，从而保持澳大利亚科学在国际上的很高知名度。 其次，我们的概念代表了治疗一系列涉及血管过度收缩的血管疾病的全新治疗潜力领域。澳大利亚药物的开发和生产将有助于国民经济，其消费可以改善那些患有血管疾病（可能包括先兆子痫、糖尿病、高血压）的人的生活质量。