Genome wide association study to explore drinking behavior in Japanese

全基因组关联研究探讨日本人的饮酒行为

• 批准号: 26253041
• 负责人: Matsuo Keitaro
• 金额: $ 26.96万
• 依托单位: Aichi Cancer Center Research Institute (2015-2016)Kyushu University (2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-26253041/
• 关键词: ALDH2; GWAS; 飲酒; polymorphism; alcohol drinking; 遺伝子多型; 飲酒習慣; 全ゲノム関連解析; 遺伝子環境要因交互作用; 飲酒行動; 日本人

项目成果

Establishment of a personialized preventive strategy of upper aerodigestive tract cancer using risk prediction model.

利用风险预测模型建立上呼吸消化道癌的个性化预防策略。

• 发表时间: 2015
• 作者: Koyanagi Y;Ito H;Oze I;Hosono S;Tanaka H;Matsuo K
• 通讯作者: Matsuo K

Alcohol and lung cancer risk among never smokers: A pooled analysis from the international lung cancer consortium and the SYNERGY study.

• DOI: 10.1002/ijc.30618
• 发表时间: 2017-05-01
• 期刊: International journal of cancer
• 影响因子: 6.4
• 作者: Fehringer G;Brenner DR;Zhang ZF;Lee YA;Matsuo K;Ito H;Lan Q;Vineis P;Johansson M;Overvad K;Riboli E;Trichopoulou A;Sacerdote C;Stucker I;Boffetta P;Brennan P;Christiani DC;Hong YC;Landi MT;Morgenstern H;Schwartz AG;Wenzlaff AS;Rennert G;McLaughlin JR;Harris CC;Olivo-Marston S;Orlow I;Park BJ;Zauderer M;Barros Dios JM;Ruano Raviña A;Siemiatycki J;Koushik A;Lazarus P;Fernández-Somoano A;Tardon A;Le Marchand L;Brenner H;Saum KU;Duell EJ;Andrew AS;Szeszenia-Dabrowska N;Lissowska J;Zaridze D;Rudnai P;Fabianova E;Mates D;Foretova L;Janout V;Bencko V;Holcatova I;Pesatori AC;Consonni D;Olsson A;Straif K;Hung RJ
• 通讯作者: Hung RJ

Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.

• DOI: 10.1038/ng.3521
• 发表时间: 2016-04
• 期刊: Nature genetics
• 影响因子: 30.8
• 作者: Dunning AM;Michailidou K;Kuchenbaecker KB;Thompson D;French JD;Beesley J;Healey CS;Kar S;Pooley KA;Lopez-Knowles E;Dicks E;Barrowdale D;Sinnott-Armstrong NA;Sallari RC;Hillman KM;Kaufmann S;Sivakumaran H;Moradi Marjaneh M;Lee JS;Hills M;Jarosz M;Drury S;Canisius S;Bolla MK;Dennis J;Wang Q;Hopper JL;Southey MC;Broeks A;Schmidt MK;Lophatananon A;Muir K;Beckmann MW;Fasching PA;Dos-Santos-Silva I;Peto J;Sawyer EJ;Tomlinson I;Burwinkel B;Marme F;Guénel P;Truong T;Bojesen SE;Flyger H;González-Neira A;Perez JI;Anton-Culver H;Eunjung L;Arndt V;Brenner H;Meindl A;Schmutzler RK;Brauch H;Hamann U;Aittomäki K;Blomqvist C;Ito H;Matsuo K;Bogdanova N;Dörk T;Lindblom A;Margolin S;Kosma VM;Mannermaa A;Tseng CC;Wu AH;Lambrechts D;Wildiers H;Chang-Claude J;Rudolph A;Peterlongo P;Radice P;Olson JE;Giles GG;Milne RL;Haiman CA;Henderson BE;Goldberg MS;Teo SH;Yip CH;Nord S;Borresen-Dale AL;Kristensen V;Long J;Zheng W;Pylkäs K;Winqvist R;Andrulis IL;Knight JA;Devilee P;Seynaeve C;Figueroa J;Sherman ME;Czene K;Darabi H;Hollestelle A;van den Ouweland AM;Humphreys K;Gao YT;Shu XO;Cox A;Cross SS;Blot W;Cai Q;Ghoussaini M;Perkins BJ;Shah M;Choi JY;Kang D;Lee SC;Hartman M;Kabisch M;Torres D;Jakubowska A;Lubinski J;Brennan P;Sangrajrang S;Ambrosone CB;Toland AE;Shen CY;Wu PE;Orr N;Swerdlow A;McGuffog L;Healey S;Lee A;Kapuscinski M;John EM;Terry MB;Daly MB;Goldgar DE;Buys SS;Janavicius R;Tihomirova L;Tung N;Dorfling CM;van Rensburg EJ;Neuhausen SL;Ejlertsen B;Hansen TV;Osorio A;Benitez J;Rando R;Weitzel JN;Bonanni B;Peissel B;Manoukian S;Papi L;Ottini L;Konstantopoulou I;Apostolou P;Garber J;Rashid MU;Frost D;EMBRACE;Izatt L;Ellis S;Godwin AK;Arnold N;Niederacher D;Rhiem K;Bogdanova-Markov N;Sagne C;Stoppa-Lyonnet D;Damiola F;GEMO Study Collaborators;Sinilnikova OM;Mazoyer S;Isaacs C;Claes KB;De Leeneer K;de la Hoya M;Caldes T;Nevanlinna H;Khan S;Mensenkamp AR;HEBON;Hooning MJ;Rookus MA;Kwong A;Olah E;Diez O;Brunet J;Pujana MA;Gronwald J;Huzarski T;Barkardottir RB;Laframboise R;Soucy P;Montagna M;Agata S;Teixeira MR;kConFab Investigators;Park SK;Lindor N;Couch FJ;Tischkowitz M;Foretova L;Vijai J;Offit K;Singer CF;Rappaport C;Phelan CM;Greene MH;Mai PL;Rennert G;Imyanitov EN;Hulick PJ;Phillips KA;Piedmonte M;Mulligan AM;Glendon G;Bojesen A;Thomassen M;Caligo MA;Yoon SY;Friedman E;Laitman Y;Borg A;von Wachenfeldt A;Ehrencrona H;Rantala J;Olopade OI;Ganz PA;Nussbaum RL;Gayther SA;Nathanson KL;Domchek SM;Arun BK;Mitchell G;Karlan BY;Lester J;Maskarinec G;Woolcott C;Scott C;Stone J;Apicella C;Tamimi R;Luben R;Khaw KT;Helland Å;Haakensen V;Dowsett M;Pharoah PD;Simard J;Hall P;García-Closas M;Vachon C;Chenevix-Trench G;Antoniou AC;Easton DF;Edwards SL
• 通讯作者: Edwards SL

A genetic polymorphism of ALDH2 and breast cancer risk: an analysis of 6,624 cases and 5,750 controls from the Breast Cancer Association Consortium

ALDH2 基因多态性与乳腺癌风险：对乳腺癌协会联盟 6,624 例病例和 5,750 名对照者的分析

• 发表时间: 2016
• 作者: Ugai T;Milne RL;Ito H;Matsuo K.
• 通讯作者: Matsuo K.

Development of a prediction model and estimation of cumulative risk for upper aerodigestive tract cancer based on aldehyde dehydrogenase 2 (ALDH2) genotype and alcohol consumption in a Japanese population

基于日本人群的乙醛脱氢酶 2 (ALDH2) 基因型和饮酒量开发预测模型并估计上呼吸消化道癌症的累积风险

• 发表时间: 2016
• 作者: Koyanagi Y;Ito H;Oze I;Hosono S;Tanaka H;Abe T;Shimizu Y;Hasegawa Y;Matsuo K.
• 通讯作者: Matsuo K.