Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter phylori-infected Mongolian Gerbils on Eradication

幽门螺杆菌（Hp）感染是导致人类胃部疾病的重要因素。蒙古沙鼠易感染Hp，可作为阐明Hp在慢性活动性胃炎、消化性溃疡、肠化生和胃癌中的作用的理想实验模型。我们已经证明了Hp感染对暴露于化学致癌物的所有组织学类型的单沙鼠胃癌的增强作用。在感染了Hp的沙鼠的腺胃中，异位增生腺（HPGs）也经常随着Hp感染而发展，其组成细胞有轻微的发育不良改变。在根除后区分可复性炎性病变和真正的肿瘤是使用该模型进行进一步的生物学或组织化学研究的必要条件。Hp感染后，蒙古沙鼠胃腺体开始向粘膜下增生，破坏肌层黏膜。该动物常见的粘膜下增生性腺体与高分化性腺瘤的组织学特征及鉴别诊断尚未见文献报道。因此，我们验证了沙鼠长期Hp感染的实验模型和适应症。根治后，胃粘膜的hpg明显减少，胃粘膜的病变也有所改善，几乎没有原损伤的残余。这一事实证明，在这一动物物种中，可逆的hpg经常仅由Hp感染引起，与严重的胃炎有关，而不是恶性的。因此，在该动物模型中，区分可逆性病变和真正的肿瘤是研究Hp感染与胃癌发生关系的必要条件。对这些病变的精确检查。HPGs，包括阐明其可能的癌前特征，将提供有关胃癌发生的新信息。利用该模型可以检测炎症、细胞增殖、细胞凋亡和生物介质的多种因素，有助于阐明胃癌发生的机制，并可能为人类癌症的预防提供坚实的基础。少

Helicobacter pylori (Hp) infection is an important factor in human gastric disorders. Mongolian gerbils can be easily infected with Hp and can be ideal experimental models to clarify the role of Hp in chronic active gastritis, peptic ulcers, intestinal metaplasia, and gastric carcinoma. We have proved the enhancing effects of Hp infection in all histological types of gastric cancers of Monogolian gerbils due to exposure to chemical carcinogens.Heterotopic Proliferative Glands (HPGs) also frequently develop with Hp infection in the glandular stomach of infected gerbils, with slightly dysplastic change of constituent cells. Distinguishing ereversible inflammatory lesions from true neoplasms upon eradication is necessary for further biological or histochemical investigations using this model. After Hp infection, glands in the stomach of Mongolian gerbils start to proliferate into the submueosa, disrupting the lamina muscularis mucosa. No papers have mentioned the histological characterist … More ics and discriminating diagnosis between these frequent submucosal proliferating glands and well-differentiated *denocareinomas in this animal species. So we verified an experimental model of long-term Hp infection and indication in gerbils. After eradication, HPGs were obviously reduced, and gastric lesions in mucosa also improved with few remnants of former injury. This fact proved the existence of reversibgle HPGs frequently induced solely with Hp infection in this animal species, related to severe gastritis, rather than malignant in character. Thus, distinguishing reversible lesions from tru neoplasms is necessary to investigate the relationship of Hp infection and gastric careinogenesis in this animal model. The precise investigation of these lesions. HPGs, including the elucidation of their possible pre-malignant characters, will provide new information concerning gastric careinogenesis. Various factors underlying inflammation, cell proliferation, apoptosis and biological mediators can be examined using the present model to help elucidate the mechanisms of gastric careinogenesis and possibly provide a lirm basis for human cancer prevention. Less