Reversibility of Heterotopic Proliferative Glands in Glandular Stomach of Helicobacter phylori-infected Mongolian Gerbils on Eradication
根除幽门螺杆菌感染蒙古沙鼠腺胃异位增殖腺的可逆性
基本信息
- 批准号:11470063
- 负责人:
- 金额:$ 7.3万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2001
- 资助国家:日本
- 起止时间:2001 至 2002
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Helicobacter pylori (Hp) infection is an important factor in human gastric disorders. Mongolian gerbils can be easily infected with Hp and can be ideal experimental models to clarify the role of Hp in chronic active gastritis, peptic ulcers, intestinal metaplasia, and gastric carcinoma. We have proved the enhancing effects of Hp infection in all histological types of gastric cancers of Monogolian gerbils due to exposure to chemical carcinogens.Heterotopic Proliferative Glands (HPGs) also frequently develop with Hp infection in the glandular stomach of infected gerbils, with slightly dysplastic change of constituent cells. Distinguishing ereversible inflammatory lesions from true neoplasms upon eradication is necessary for further biological or histochemical investigations using this model. After Hp infection, glands in the stomach of Mongolian gerbils start to proliferate into the submueosa, disrupting the lamina muscularis mucosa. No papers have mentioned the histological characterist … More ics and discriminating diagnosis between these frequent submucosal proliferating glands and well-differentiated *denocareinomas in this animal species. So we verified an experimental model of long-term Hp infection and indication in gerbils. After eradication, HPGs were obviously reduced, and gastric lesions in mucosa also improved with few remnants of former injury. This fact proved the existence of reversibgle HPGs frequently induced solely with Hp infection in this animal species, related to severe gastritis, rather than malignant in character. Thus, distinguishing reversible lesions from tru neoplasms is necessary to investigate the relationship of Hp infection and gastric careinogenesis in this animal model. The precise investigation of these lesions. HPGs, including the elucidation of their possible pre-malignant characters, will provide new information concerning gastric careinogenesis. Various factors underlying inflammation, cell proliferation, apoptosis and biological mediators can be examined using the present model to help elucidate the mechanisms of gastric careinogenesis and possibly provide a lirm basis for human cancer prevention. Less
幽门螺杆菌(Helicobacter pylori,Hp)感染是引起人类胃病的重要因素。蒙古沙土鼠是Hp感染的易感动物,是研究Hp在慢性活动性胃炎、消化性溃疡、肠上皮化生和胃癌中作用的理想实验模型。实验证明,Hp感染对化学致癌物诱发的蒙古沙鼠胃癌的各种组织学类型均有促进作用,感染后的沙鼠腺胃也常出现异位性消化腺(Heterotopic Precipitative Glands,HPGs),其组成细胞有轻度的异型增生。区分不可逆的炎症病变从真正的肿瘤根除是必要的进一步生物学或组织化学研究使用这个模型。感染Hp后,沙鼠胃内腺体开始增生,进入粘膜下层,破坏粘膜肌层。组织学特征未见文献报道 ...更多信息 在这种动物种属中,这些频繁的粘膜下增生腺体和分化良好的腺癌之间的鉴别诊断。因此,我们在沙鼠中验证了长期Hp感染的实验模型和适应症。根除后,HPGs明显减少,胃粘膜病变也有所改善,原有损伤残留较少。这一事实证明,该动物种属中存在仅由Hp感染引起的可逆性HPGs,其与重度胃炎有关,而不是恶性的。因此,区分可逆性病变和tru肿瘤是必要的,以研究Hp感染与胃癌发生的关系,在这个动物模型。对这些损伤的精确检查。HPGs,包括阐明其可能的癌前特征,将提供有关胃癌发生的新信息。利用本模型可以检测炎症、细胞增殖、凋亡和生物介质等多种因素,有助于阐明胃癌发生的机制,并可能为人类癌症的预防提供可靠的依据。少
项目成果
期刊论文数量(52)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Yuzuru Ikehara: "Polymorphisms of Two Fucosyl Transferase Genes (Lewis and Secretor Genes) Involving Type I Lewis Antigens Are Associated with eh Presence of Anti-Helicobacter Pylori IgG Antibody"Cancer Epidemiol Biomarkers Prev.. 10(9). 971-977 (2001)
Yuzuru Ikehara:“涉及 I 型 Lewis 抗原的两个岩藻糖基转移酶基因(Lewis 和分泌基因)的多态性与抗幽门螺杆菌 IgG 抗体的存在相关”癌症流行病学生物标志物 Prev.. 10(9)。
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Ken-Ichi Inada: "Identification of Paneth cells in pylotic glands associated with gastric and intestinal mixed-type intestinal metaplasia of the human stomach"Virchows Arch.. 439(1). 14-20 (2001)
Ken-Ichi Inada:“与人胃的胃和肠混合型肠化生相关的幽门腺中潘氏细胞的鉴定”Virchows Arch.. 439(1)。
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- 影响因子:0
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稲田健一: "Identification of Paneth cells in pyloric glands associated with gastric and intestinal mixed type intestinal metaplasia of the human stomach."Virchows Archives. inpress. (2001)
Kenichi Inada:“幽门腺中与胃和肠混合型肠化生相关的潘氏细胞的鉴定。”Virchows Archives(2001)。
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- 影响因子:0
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Tetsuya Okino: "Sequential Histopathological Changes in vivo after Suicide Gene Therapy of Gastric Cancer Induced by N-Methyl-N'-nitro-N-nitrosoguanidine in Rats"Jpn J Cancer Res.. 92(6). 673-679 (2001)
Tetsuya Okino:“大鼠体内N-甲基-N-硝基-N-亚硝基胍诱导的胃癌自杀基因治疗后体内的连续组织病理学变化”Jpn J Cancer Res.. 92(6)。
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- 影响因子:0
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塚本徹哉: "More frequent β-catenin gene mutations in adenomas than in aberrant crypt foci or adenocarcinomas in the large intestines of 2-amino-1-methyl-6-phenylimidazo [4,5-b] pyridine (PhIP)-treated rats."Japanese Journal of Cancer Research . 91. 665-673 (2
Tetsuya Tsukamoto:“在经过 2-氨基-1-甲基-6-苯基咪唑[4,5-b]吡啶 (PhIP) 治疗的大鼠的大肠中,腺瘤中的 β-连环蛋白基因突变比异常隐窝病灶或大肠腺癌中更常见.“日本癌症研究杂志。91. 665-673 (2
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TATEMATSU Masae其他文献
TATEMATSU Masae的其他文献
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{{ truncateString('TATEMATSU Masae', 18)}}的其他基金
The mechanism of the development of gastric-and-intestinal mixed intestinal metaplasia-the analysis of homeobox genes in the isolated pyloric glands-
胃肠混合性肠化生的发生机制-离体幽门腺同源框基因分析-
- 批准号:
15390121 - 财政年份:2003
- 资助金额:
$ 7.3万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Gene alterations during stomach carciro genesis in H. pyrori infected Mongolian gerbik
幽门螺杆菌感染蒙古沙鼠胃癌发生过程中的基因改变
- 批准号:
12213164 - 财政年份:2000
- 资助金额:
$ 7.3万 - 项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
Development and Genetic Changes of Isolated Aberrant Crypts Based on Clonal Analysis
基于克隆分析的分离异常隐窝的发育和遗传变化
- 批准号:
08670270 - 财政年份:1996
- 资助金额:
$ 7.3万 - 项目类别:
Grant-in-Aid for Scientific Research (C)
Monoclonal growth during chimeric mouse carcinogenesis demonstrated by a strain-specific antibody and microsatellite DNA polymorphism patterns.
通过品系特异性抗体和微卫星 DNA 多态性模式证明嵌合小鼠致癌过程中的单克隆生长。
- 批准号:
06670250 - 财政年份:1994
- 资助金额:
$ 7.3万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
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8397754 - 财政年份:2012
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