Switching of spatio-temporal Rho GTPase signal network dynamics during cell cycle phase transitions (A08)

Nalbant旨在揭示在生理和病理生理背景下细胞状态转变过程中，细胞骨架调节因子和基本细胞形状变化的时空活动动态是如何被控制的。由于细胞形状变化是由肌动蛋白丝的动态重排驱动的，而肌动蛋白丝的动态重排又受Rho GTPase信号网络的控制，她将研究Rho活性动力学的功能及其由鸟嘌呤核苷酸交换因子的复杂调节，以及它们是如何被触发的，并利用先进的活细胞显微镜和急性光遗传调节与剧烈的细胞状态转变联系在一起。

Nalbant aims to unravel how spatio-temporal activity dynamics of cytoskeletal regulators and fundamental cell shape changes are controlled during cell state transitions in physiological and pathophysiological contexts. Because cell shape changes are driven by dynamic rearrange-ments of actin filaments that in turn are controlled by Rho GTPase signal networks, she will study the function of Rho activity dynamics and their complex regulation by guanine nucleotide exchange factors and how they are triggered and linked to the dramatic cell state transitions utilizing advanced live-cell microscopy and acute optogenetic modulation.