Worksite cohort study for evaluation of lifestyle-related diseases risk : effect of lifestyle modification on the insulin level and the manifestation of metabolic syndrome

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We started a worksite-based cohort study of 11,000 people in 1997 by constructing database consisting of annual health check-up data and affairs of coronary heart disease(CHD) and stroke under the approval of ethical committee. In 1997 and 2002,questionnaire survey on lifestyle and storage of frozen serum samples for later determination of insulin, leptin, CRP, etc was done.The following results were obtained, 1)Self-reported incident cases of CHD and stroke during the first 5 years accounted 52 and 36,respectively, including 15 myocardial infarctions, 14 angina pectoris, etc according to questionnaire survey. Consistency of the report with the answers from their family doctors was 100% for myocardial infarction, cerebral infarction and subarachnoid hemorrhage as long as cases examined under informed consent were concerned. Consistency for hypertension, diabetes, hyperlipidemia, and hyperuricemia all exceeded 95%. 2)The weight variability during 20 to 40 years since the age of 20 was a … More significant predictor of subsequent appearance of elevated serum insulin and CRP levels and metabolic syndrome(MS) independent of weight change slope or resultant BMI in 2,000 people, suggesting the importance of maintaining constant weight since the youth to prevent atherosclerosis. 3)Although the development of MS was associated with the increase in white blood cell(WBC) counts and CRP, insulin levels was not associated with the WBC counts in 3,500 people. Insulin, hence, was supposed to cause low grade inflammation or atherosclerosis through development of MS. Leptin was associated with the increase of WBC counts independently of obesity. 4)The association of blood pressure with likeness of salty taste was intensified in females aged 50 years or older, suggesting the effects of menopause on the salt sensitivity. 5)Serum phospholipids transfer protein showed strong correlations with serum lipids and BMI and an inverse correlation with the development of CHD but no correlation with that of stroke during 37 months' follow up of 2,600 people. 6)The reproducibility and validity of simple check-list type questionnaire of food intake and dietary behavior used in this study was confirmed. From the comparison of self-reported and measured weights at age 20,reliability of self-reported weights was confirmed. Less