Investigation for the development of the method of evaluating regional lung function in the upright position using vertically opened MR system.

研究开发使用垂直开放式 MR 系统评估直立位局部肺功能的方法。

• 批准号: 13470182
• 负责人: MURATA Kiyoshi
• 金额: $ 3.9万
• 依托单位: Shiga University of Medical Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470182/
• 关键词: Vertically opened MR; Upright MR imaging; Diaphragmatic motion

To determine the postural difference of diaphragmatic motion between the sitting and supine position, ten healthy men were examined using a vertically open 0.5-T MR system and an original sitting chair device and a special surface coil. Forty sequential MR images were obtained both in the sitting and supine positions during 2-5 respiratory cycles. The diaphragmatic excursions (D.E.) were measured on 3 diaphragmatic points of 6 sagittal planes for both positions. The difference of D.E.between the anterior and posterior parts of the diaphragm were also determined. D.E.in the supine position was significantly greater than that in the sitting position at 16 of the 18 points. In 5 of the 6 sagittal planes, the difference of DE between posterior and anterior points was significantly larger in the supine position than in the sitting position.In the preoperative lung cancer patients, D.E.in the supine position was significantly (p<0.5) greater than in the sitting position at 10 of the 12 points. D.E.in the postoperative lung was significantly (p<0.5) smaller than that in the pre-operative state at 5 of the 6 points(supine) and at 4 of the 6 points(sitting). In the patients with phrenic nerve paralysis, D.E.was significantly greater(p<0.5) in the sitting position at 5 of the 6 points. In addition, the decrease of diaphragmatic motion in patients with pulmonary emphysema was also demonstrated in both supine and sitting positions.MR imaging in the sitting position may provide the additional information about the mechanism of abnormal diaphragmatic motion caused by various diseases.

为了确定坐位和仰位时横隔膜运动的姿势差异，对10名健康男性进行了检查，采用0.5T垂直开放式磁共振系统、原装坐椅装置和特殊的表面线圈。在2~5个呼吸周期中，共获得了40个坐位和仰卧位的MR序列图像。横隔膜偏移(D.E.)在6个矢状面的3个横隔点上对两个位置进行测量。并测定了横隔膜前后部的差值。在18分中的16分，仰卧位的DEE明显大于坐位。在6个矢状位中，有5个仰卧位的前后位DE差值明显大于坐位，肺癌患者术前仰卧位的DE明显大于坐位(P<0.0 5)。术后6个点中的5个点(仰卧位)和4个点(坐位点)术后肺的D.E.均明显小于术前状态(P<0.05)。在膈神经麻痹患者中，坐位6个点中有5个点的运动诱发电位明显大于坐位(p&lt；0.5)。此外，肺气肿患者卧位和坐位时的横隔膜运动均有不同程度的降低，坐位MR成像可提供各种疾病引起的横隔膜运动异常的机制方面的补充信息。

项目成果

村田喜代史, 高橋雅士, 井藤隆太, 高櫻竜太郎: "開放型MR装置を用いた立位における局所肺機能評価法の開発に関する研究"Innervision. 18. 38 (2003)

Kiyoshi Murata、Masashi Takahashi、Ryuta Ito、Ryutaro Takasakura：“使用开放式 MR 设备进行站立位局部肺功能评估方法的开发研究”Innervision 18. 38 (2003)。

Takazakura R, Takahashi M, Nitta N, and Murata K.: "Comparison of the diaphragmatic motion between the sitting and supine position in normal volunteers using a vertically opened MR system"The 61th annual meeting of Japan Radiological Society. April. 5 (20

Takazakura R、Takahashi M、Nitta N 和 Murata K.：“使用垂直开放 MR 系统对正常志愿者坐位和仰卧位之间的膈肌运动进行比较”日本放射线学会第 61 届年会。

Takazakura R, et al.: "Comparisonof the diaphragmatic motion between the sitting and supine position in normal volunteers using a vertically opened MR system"Radiology. 221(P). 537 (2001)

Takazakura R 等人：“使用垂直打开的 MR 系统对正常志愿者坐姿和仰卧位置之间的膈肌运动进行比较”放射学。

Takazakura R, Takahashi M, Nitta N, Shimizu K, and Murata K.: "Comparison of the Diaphragmatic Motion between the Sitting and Supine position in Normal Volunteers using a Vertically Opened MR system"The annual meeting of Radiological Society of North Amer

Takazakura R、Takahashi M、Nitta N、Shimizu K 和 Murata K.：“使用垂直开放 MR 系统比较正常志愿者坐姿和仰卧位置之间的膈肌运动”北美放射学会年会

Takazakura R, Takahashi M, Nitta N, Nishimoto Y, and Murata K.: "Comparison of the Diaphragmatic Motion between the Sitting and Supine position using a Vertically Opened MR system - Normal volunteer and initial clinical experience"The annual meeting of th

Takazakura R、Takahashi M、Nitta N、Nishimoto Y 和 Murata K.：“使用垂直开放 MR 系统对坐位和仰卧位之间的膈肌运动进行比较 - 正常志愿者和初步临床经验”年会