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Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal

Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal
非清髓性同种异体造血干细胞移植治疗难治性胃肠道疾病的临床研究进展
批准号:
13470259
负责人:
YAMAGISHI Hisakazu
金额:
$3.46万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2003

项目摘要

项目成果

相关文献

中文摘要
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英文摘要
Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.
期刊论文(22)
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Kenichi Nomura, et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sectione."Cancer Genetics Cytogenetics. 140. 49-54 (2003)
Kenichi Nomura 等人:“石蜡包埋组织切片上粘膜相关淋巴细胞组织类型边缘区淋巴瘤中 t(11;18)(q21;q21) 的检测”。癌症遗传学细胞遗传学。
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Imashuku S, Naya M, Tamura S, An B, Teramura T, Kobayashi M, Nomura K, Taniwaki M.: "Effectiveness of Rituximab for chemotherapy-resistant multiple tumoral B-LPD in a hematopoietic stem cell recipient"Br J Haematol. 117. 768-774 (2002)
Imashuku S、Naya M、Tamura S、An B、Teramura T、Kobayashi M、Nomura K、Taniwaki M.:“利妥昔单抗对造血干细胞受体中化疗耐药的多发肿瘤 B-LPD 的有效性”Br J Haematol。
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上田 祐二: "造血幹細胞移植の現状と今後の展望〜樹状細胞を用いて免疫細胞療法〜"医薬ジャーナル37(3). 37(3). 179-183 (2001)
Yuji Ueda:“造血干细胞移植的现状和未来前景 - 使用树突状细胞的免疫细胞治疗”,Pharmaceutical Journal 37(3) 179-183 (2001)。
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