Clinical Research on the Development of Non-myeloablative Allogeneic Hematopoietic Stem Cell Transplantation for Refractory Gastrointestinal

非清髓性同种异体造血干细胞移植治疗难治性胃肠道疾病的临床研究进展

• 批准号: 13470259
• 负责人: YAMAGISHI Hisakazu
• 金额: $ 3.46万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470259/
• 关键词: Gastrointestinal Cancer; A1logeneic_Hematopoietic Stem Cell Transplantation; Immunotherapy; Mini-transplantation; Graft-versus-Tumor Effect

Non-myeloablative allogeneic hematopoietic stem cell transplantation for refractory colon cancer was performed. The patient was a 45-year-old female with metastatic colon cancer. Metastatic sites were located in the liver, lymph nodes, and intra-peritoneal cavity (peritoneal dissemination). The donor was her HLA full-matched elder brother. After non-myeloablative and immunosuppressive chemotherapy with cyclophosphamide and fludarabine, allogeneic peripheral blood stem cell transplantation was performed (mini-transplantation). Although graft-versus-host disease (GVHD) was recognized 35 days after transplantation, tumor shrinkage didn't occur and she died of cancer 64 days after transplantation.

采用非清髓性异基因造血干细胞移植治疗难治性结肠癌。患者是一名45岁的女性，患有转移性结肠癌。转移部位位于肝脏、淋巴结和腹膜腔内（腹膜播散）。供体是她的HLA完全匹配的哥哥。经环磷酰胺和氟达拉滨非清髓性免疫抑制化疗后，行异基因外周血干细胞移植（迷你移植）。虽然移植后35天发现移植物抗宿主病（GVHD），但肿瘤没有缩小，移植后64天死于癌症。

项目成果

Nomura K, Yoshino T, Nakamura S, Akano Y, Tagawa H, Nishida K, Seto M, Nakamura S, Ueda R, Yamagishi H, Taniwaki M.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue section

Nomura K、Yoshino T、Nakamura S、Akano Y、Takawa H、Nishida K、Seto M、Nakamura S、Ueda R、Yamagishi H、Taniwaki M.：“在边缘检测 t(11;18)(q21;q21)

Kenichi Nomura, et al.: "Detection of t(11;18)(q21;q21) in marginal zone lymphoma of mucosa-associated lymphocytic tissue type on paraffin-embedded tissue sectione."Cancer Genetics Cytogenetics. 140. 49-54 (2003)

Kenichi Nomura 等人：“石蜡包埋组织切片上粘膜相关淋巴细胞组织类型边缘区淋巴瘤中 t(11;18)(q21;q21) 的检测”。癌症遗传学细胞遗传学。

Imashuku S, Naya M, Tamura S, An B, Teramura T, Kobayashi M, Nomura K, Taniwaki M.: "Effectiveness of Rituximab for chemotherapy-resistant multiple tumoral B-LPD in a hematopoietic stem cell recipient"Br J Haematol. 117. 768-774 (2002)

Imashuku S、Naya M、Tamura S、An B、Teramura T、Kobayashi M、Nomura K、Taniwaki M.：“利妥昔单抗对造血干细胞受体中化疗耐药的多发肿瘤 B-LPD 的有效性”Br J Haematol。

上田 祐二: "造血幹細胞移植の現状と今後の展望〜樹状細胞を用いて免疫細胞療法〜"医薬ジャーナル37(3). 37(3). 179-183 (2001)

Yuji Ueda：“造血干细胞移植的现状和未来前景 - 使用树突状细胞的免疫细胞治疗”，Pharmaceutical Journal 37(3) 179-183 (2001)。

Shinsaku Imashuku, et al.: "Effectiveness of RITUXIMAB for chemotherapy-resistant multiple tumoral B-LPD in a haematopoietic stem cell recipient."British Journal of Hematology. 117. 771-773 (2002)

Shinsaku Imashuku 等人：“RITUXIMAB 对造血干细胞受体中化疗耐药的多发肿瘤 B-LPD 的有效性。”英国血液学杂志。