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Development of cancer specific vector for lung carcinoma by inducing RCAS1 ligand and SCCA promoter

Development of cancer specific vector for lung carcinoma by inducing RCAS1 ligand and SCCA promoter
通过诱导RCAS1配体和SCCA启动子开发肺癌特异性载体
批准号:
13470265
负责人:
MORIKAWA Toshiaki
金额:
$9.34万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2001
资助国家:
日本
项目状态:
已结题
起止时间:
2001 至 2002

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中文摘要
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英文摘要
We made a replication-deficient recombinant adenovirus driven by the squamous cell carcinoma antigen (SCCA) promoter (Ad SCCA-KLAKLAK2). We demonstrated that the expression of KLAKLAK2 and growth inhibition were all specific to lung cancer cell lines that were SCCA positive, whereas no growth retardation was observed in human normal cell lines after Ad SCCA-KLAKLAK2 infection.Therapeutic effect was observed also in the nude mice zenograft model. Tumor growth was inhibited in the SCCA positive cell lines and side effects of the vector were not observed.
期刊论文(16)
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会议论文
Masato Suzuoki: "Impact of caveolin-1 expression on prognosis of pancreatic ductal adenocarcinoma"British Journal of Cancer. 87. 1140-1144 (2002)
Masato Suzuoki:“caveolin-1 表达对胰腺导管腺癌预后的影响”英国癌症杂志。
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Kei Hiraoka: "Solitary fibrous tumors of the pleura : clinicopathological and immunohistochemical examination"Interactive Cardiovascular and thoracic Surgery. 2. 61-64 (2003)
Kei Hiraoka:“胸膜孤立性纤维瘤:临床病理学和免疫组织化学检查”交互式心血管和胸外科。
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Kei Hiraoka: "High expression of tumor-associated antigen RCAS1 in pancreatic ductal adenocarcinoma in an unfavorable prognostic marker"International Journal of Cancer. 99. 418-423 (2002)
Kei Hiraoka:“胰腺导管腺癌中肿瘤相关抗原 RCAS1 的高表达是不利的预后标志物”国际癌症杂志。
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