Study of underlying electrical pattern of chronic atrial fibrillation and development of new surgical radio-frequency ablation system

慢性心房颤动潜在电模式的研究及新型外科射频消融系统的开发

基本信息

批准号：
13470275
负责人：
SUEDA Taijiro
金额：
$ 5.44万
依托单位：
HIROSHIMA UNIVERSITY
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2002
项目状态：
已结题

项目摘要

We have performed intraoperative atrial mapping in the cases of atrial fibrillation (Af) associated with organic heart disease and analyzed electrophysiological and clinical data in last decade. In this study, we continued these investigations and developed new analysis methods.To visualize the electrophysiological characteristics, especially the "repetitive" and "frequent" activation, of chronic atrial fibrillation (Af) associated with or without organic heart disease, we mapped atrial electrical activity from atrial surface during atrial fibrillation by means of multi-point electrodes and specially made mapping system. Data were mainly acquired from the atrial free wall of both atria and anatomical obstacles, such as the orifice of pulmonary veins or crista terminalis, and were analyzed by specially designed software using spectrum analysis. Then we analyzed clinical outcome of pulmonary vein orifice isolation (PVO1), a less invasive simple surgical procedure that we developed and pe … More rformed, for chronic Af wilh the data from electrophysiological analysis. Moreover, we examined the delivery system of surgical radio frequency ablation with experimental and clinical analysis.Intraoperative visualization of repetitive activation of Af was useful for intraoperative decision of the ablation line. The results of analysis from clinical and electrophysiological data suggested that Af was highly diminished with PVO1, which showed more organic pattern in both atrial electric activation. The visualization mapping system can recognize the atrial organization. We believe that this outcome is useful for "Order Made Procedure" for chronic Af.Otherwise, we showed that the intraoperative radio frequency delivering was enough to create complete ablation line with the system now in use in the experimental and clinical study. However, we noted that low energy delivery possibly make incomplete block line. Then we supposed that the development of new ablation device for various block lines or for epicardial ablation is needed. Less

在过去的十年中，我们在与有机心脏病相关的心房颤动（AF）的情况下进行了术中的心房映射（AF）。在这项研究中，我们继续进行了这些研究并开发了新的分析方法。为了可视化电生理特征，尤其是慢性心房颤动（AF）的“重复”和“频繁”激活，我们与有机心脏病相关的慢性心房颤动（AF），我们通过倍增和专用于多动物的型号和特种型物质绘制了心房表面的心房电活动。数据主要是从心房和解剖障碍物（例如肺静脉或CRISTA末端的孔口）中获得的，并使用Spectrum Analysis进行了特殊设计的软件分析。然后，我们分析了肺静脉孔分离（PVO1）的临床结局，这是一种侵入性的简单外科手术，我们开发了和PE……更加成熟，以慢性化，从电生理分析中获得数据。此外，我们通过实验和临床分析检查了手术射频消融的输送系统。AF的重复激活的Intraerative可视化对消融线的术中决策很有用。来自临床和电生理数据的分析结果表明，PVO1高度降低了AF，这在两种心房电动激活中都显示出更多的有机模式。可视化映射系统可以识别心房组织。我们认为，这种结果对于慢性AF的“订单制作程序”很有用。但是，我们注意到可能的低能输送可能会导致不完整的区块线。然后，我们希望需要开发用于各种区块线或心外膜消融的新消融设备。较少的