Medical Application of New Technology for imaging second messenger system by Positron Emission Tomography

PET第二信使成像在脑功能研究、心肌重构和肿瘤诊断等方面的临床应用已得到证实。细胞培养和动物模型的基础研究表明，^<11 b> C标记的1,2-二酰基甘油（[^<11>C]DAG）对PLC活性的反应和^<18>F标记的1,2-二酰基甘油（[^<18>F]FDAG）对PLD活性的反应。[^<11>C]DAG作为潜在的成像示踪剂用于健康正常人和脑卒中、帕金森病、阿尔茨海默病等各种疾病的人脑突触后生物学反应。[^<11>C]DAG在心肌梗死（MI）中的研究表明，该技术可用于在心肌梗死后心室重构过程中视觉检测PI代谢激活的区域。[^<18>F]FDAG应用于肿瘤检测，基于培养细胞、肿瘤组织和动物模型对PLD活性的反应，结果表明[^<18>F]FDAG可作为早期肿瘤生长的潜在成像示踪剂。为了促进动力学分析的临床应用，开发了简化的PET-MR融合成像计算机程序。第二信使系统的医学成像技术将成为医学诊断各个领域的新前沿。

Clinical applications of second messenger imaging by PET has been demonstrated in the fields of brain function study, myocardial remodeling and tumor diagnosis. Basic study of cell culture and animal model made clear that the imaging by ^<11>C-labeled 1,2-diacylglycerol ([^<11>C]DAG) response to PLC activity and ^<18>F-labeled 1,2-diacylglycerol ([^<18>F]FDAG) response to PLD activity. [^<11>C]DAG is used as potential imaging tracers for postsynaptic biological responses in human brain of healthy normal subjects and with various diseases such as stroke, Parkinson's and Alzheimer's disease. The [^<11>C]DAG study in myocardial infarction(MI) suggested that this technology may be useful for visually detecting regions with activated PI metabolism in the process of ventricular remodeling after MI.[^<18>F]FDAG applied to tumor detection based on the response to PLD activity in cultured cell, tumor tissues and animal models and the results suggested that [^<18>F]FDAG are used as potential imaging tracers for early stage of tumor growth.The simplified PET-MR fusion imaging computer program has been developed to promote clinical application of kinetic analysis.This technology for medical imaging of second messenger systems will be new frontier in various fields of rmedical diagnosis.