Medical Application of New Technology for imaging second messenger system by Positron Emission Tomography

PET第二信使成像已在脑功能研究、心肌重塑和肿瘤诊断等领域得到临床应用。细胞培养和动物模型的基础研究表明，11&gt；C标记的1，2-二酰甘油([^&lt；11&gt；C]DAG)对PLC活性的显影和^&lt；18&gt；F标记的1，2-甘油([^&lt；18&gt；F]FDAG)对PLD活性的显影。[^&lt；11&gt；C]DAG被用来作为潜在的成像示踪剂，用于研究健康正常人以及中风、帕金森和阿尔茨海默病等各种疾病的人脑突触后生物学反应。对心肌梗死(MI)的DAG研究表明，这项技术可能有助于直观地检测MI后心室重构过程中PI代谢激活的区域。FDAG应用于肿瘤检测，是基于培养细胞、肿瘤组织和动物模型对PLD活性的反应，结果表明[^&lt；18&gt；FDAG是肿瘤生长早期潜在的影像示踪剂。简化的PET-MR融合成像计算机程序已被开发出来，以促进动力学分析的临床应用。这项第二信使系统的医学成像技术将成为各种医学诊断领域的新前沿。

Clinical applications of second messenger imaging by PET has been demonstrated in the fields of brain function study, myocardial remodeling and tumor diagnosis. Basic study of cell culture and animal model made clear that the imaging by ^<11>C-labeled 1,2-diacylglycerol ([^<11>C]DAG) response to PLC activity and ^<18>F-labeled 1,2-diacylglycerol ([^<18>F]FDAG) response to PLD activity. [^<11>C]DAG is used as potential imaging tracers for postsynaptic biological responses in human brain of healthy normal subjects and with various diseases such as stroke, Parkinson's and Alzheimer's disease. The [^<11>C]DAG study in myocardial infarction(MI) suggested that this technology may be useful for visually detecting regions with activated PI metabolism in the process of ventricular remodeling after MI.[^<18>F]FDAG applied to tumor detection based on the response to PLD activity in cultured cell, tumor tissues and animal models and the results suggested that [^<18>F]FDAG are used as potential imaging tracers for early stage of tumor growth.The simplified PET-MR fusion imaging computer program has been developed to promote clinical application of kinetic analysis.This technology for medical imaging of second messenger systems will be new frontier in various fields of rmedical diagnosis.