Medical Application of New Technology for imaging second messenger system by Positron Emission Tomography

PET第二信使显像在脑功能研究、心肌重塑和肿瘤诊断等方面的临床应用已得到证实。细胞培养和动物模型的基础研究表明，<11>1，2-二酰甘油（[^<11>C]DAG）对PLC活性的显像反应和<18>1，2-二酰甘油（[^<18>F]FDAG）对PLD活性的显像反应。DAG<11>被用作健康正常受试者和患有各种疾病如中风、帕金森病和阿尔茨海默病的人脑中突触后生物反应的潜在成像示踪剂。心肌<11>梗死（MI）的[^ C]DAG研究表明，该技术可能有助于直观地检测MI后心室重塑过程中PI代谢活化的区域。基于<18>对培养细胞、肿瘤组织和动物模型中PLD活性的响应，将[^ F]FDAG应用于肿瘤检测，并且结果表明[^<18>F]FDAG用作肿瘤生长早期的潜在成像示踪剂。磁共振融合成像计算机程序的开发，将推动动力学分析的临床应用，这一技术用于第二信使系统的医学成像，将是各种医学成像领域的新前沿医学诊断领域。

Clinical applications of second messenger imaging by PET has been demonstrated in the fields of brain function study, myocardial remodeling and tumor diagnosis. Basic study of cell culture and animal model made clear that the imaging by ^<11>C-labeled 1,2-diacylglycerol ([^<11>C]DAG) response to PLC activity and ^<18>F-labeled 1,2-diacylglycerol ([^<18>F]FDAG) response to PLD activity. [^<11>C]DAG is used as potential imaging tracers for postsynaptic biological responses in human brain of healthy normal subjects and with various diseases such as stroke, Parkinson's and Alzheimer's disease. The [^<11>C]DAG study in myocardial infarction(MI) suggested that this technology may be useful for visually detecting regions with activated PI metabolism in the process of ventricular remodeling after MI.[^<18>F]FDAG applied to tumor detection based on the response to PLD activity in cultured cell, tumor tissues and animal models and the results suggested that [^<18>F]FDAG are used as potential imaging tracers for early stage of tumor growth.The simplified PET-MR fusion imaging computer program has been developed to promote clinical application of kinetic analysis.This technology for medical imaging of second messenger systems will be new frontier in various fields of rmedical diagnosis.