Development of a SIgA measurement kit for monitoring of risk of URTI

开发用于监测 URTI 风险的 SIgA 测量套件

• 批准号: 13558003
• 负责人: KONO Ichiro
• 金额: $ 3.65万
• 依托单位: University of Tsukuba (2003)The University of Tokyo (2001-2002)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13558003/
• 关键词: URTI; SIgA; sports; athletes; immunity; saliva; 免疫; 感染症; スポーツ; 運動; 局所免疫; 唾液

Development of SIgA kitWe tried to develop a SIgA measurement kit by using commercially available monoclonal antibody. However, we could not develop an optimal system of SIgA measurement, because of the titer and/or epitope of monoclonal antibody. So, we are trying to make some monoclonal antibodies to be able to use TIA. Now we are screening the antibodyDetermination of the relationship between SIgA level and URTIOur research which we pointed out the relationship between SIgA and URTI, was published in Japanese Journal of Clinical Sports Medicine. Furthermore, another research which dealt with changes of SIgA and physical and mental stress was published in Medicine and Science in Spurts and Exercise. Resulting from this study, we clarified that there is a certain relationship between SIgA level and risk of URTI, we may be able to apply the relationship to prevent URTI in athletes

SIgA基特韦的开发我们尝试通过使用市售的单克隆抗体开发SIgA测量试剂盒。然而，由于单克隆抗体的滴度和/或表位的限制，我们无法建立最佳的SIgA检测系统。因此，我们正在尝试制造一些单克隆抗体，以便能够使用TIA。我们的研究指出了SIgA和URTI之间的关系，并发表在日本临床运动医学杂志上。此外，另一项关于SIgA变化和身心压力的研究发表在《突发和运动中的医学和科学》上。本研究结果表明，运动员血清SIgA水平与URTI的发生有一定的相关性，可应用于运动员URTI的预防

项目成果

T Akimoto, Y Kumai, T Akama, E Hayashi, H Murakami, R Soma, S Kuno, I Kono: "Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects"Br.J. Sports Med.. 37(2). 76-79 (2003)

T Akimoto、Y Kumai、T Akama、E Hayashi、H Murakami、R Soma、S Kuno、I Kono：“12 个月的运动训练对老年受试者唾液分泌 IgA 水平的影响”Br.J.

中村大輔, 秋本崇之: "大学サッカー選手における唾液中SIgAを用いた上気道感染症予防の試み"日本臨床スポーツ医学会誌. 10(3). 445-450 (2002)

Daisuke Nakamura、Takayuki Akimoto：“利用大学足球运动员唾液 SIgA 预防上呼吸道感染的尝试”，日本临床运动医学会杂志 10(3) (2002)。

T Akimoto, Y Kumai, T Akama, E Hayashi, H Murakami, R Soma, S Kuno, I Kono: "affects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects"Br.J.Sports Med.. 37(2). 76-79 (2003)

T Akimoto、Y Kumai、T Akama、E Hayashi、H Murakami、R Soma、S Kuno、I Kono：“12 个月的运动训练对老年受试者唾液分泌 IgA 水平的影响”Br.J.Sports Med.. 37

T Akimoto, Y Kumai, T Akama, E Hayashi, H Murakami, R Soma, S Kuno, I Kono: "Effects of 12 months of exercise training on salivary secretory IgA levels in elderly subjects"Br.J.Sports Med.. 37(2). 76-79 (2003)

T Akimoto、Y Kumai、T Akama、E Hayashi、H Murakami、R Soma、S Kuno、I Kono：“12 个月运动训练对老年受试者唾液分泌 IgA 水平的影响”Br.J.Sports Med.. 37

秋本崇之, 扇原淳: "運動は免疫能を向上させるか?疫学によるエビデンス"臨床スポーツ医学. 19(11). 1283-1287 (2002)

Takayuki Akimoto，Jun Ogihara：“运动能改善免疫功能吗？流行病学证据”19(11) 1283-1287 (2002)。