Practical synthetic methodology using a divalent titanium compound
使用二价钛化合物的实用合成方法
基本信息
- 批准号:15350054
- 负责人:
- 金额:$ 9.22万
- 依托单位:
- 依托单位国家:日本
- 项目类别:Grant-in-Aid for Scientific Research (B)
- 财政年份:2003
- 资助国家:日本
- 起止时间:2003 至 2004
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
The following new synthetic methods using a divalent titanium complex have been developed1)A facile method for synthesizing benzyltitanium complex from internal acetylenes, terminal acetylenes and propargyl bromides was developed. The method allowed to prepare poly-substituted benzene derivatives.2)The reaction of internal acetylenes, terminal acetylene and sulphonitrile in the presence of the divalent titanium reagent afforded pyridinyl titanium reagents, thus allowing to easy access to pyridine derivatives.3)π-Conjugated oligomers having enyne-, endiyne-, heteroaromatic-enyne units were prepared using a 1-iodo-3-yne-1-alkaene as building block.4)Regio-selective reactions of 1,4-diiodo-1,3-alkadienes were developed which included regio-selective coupling reactions with cuprates, and with Grignard reagents in the presence of a catalytic amount of Pd-catalysis. The regioselective magnesiation of 1-iodo-1,3-alkadienes with a magnesium ate complex was also developed.
1)以内炔、末端炔和炔丙基溴为原料,合成了苄基钛配合物。该方法允许制备多取代苯衍生物。2)在二价钛试剂的存在下,内部乙炔、末端乙炔和硫腈的反应得到吡啶基钛试剂,从而允许容易地获得吡啶衍生物。3)具有烯炔-、烯二炔-、烯二炔-的π-共轭低聚物,使用1-碘-3-炔-1-烯烃作为结构单元制备杂芳族-烯炔单元。4)1,4-二碘-1,发展了3-链二烯,包括与铜酸盐的区域选择性偶联反应,以及在催化量的Pd催化剂存在下与格氏试剂的区域选择性偶联反应。研究了1-碘-1,3-链二烯与镁络合物的区域选择性镁化反应。
项目成果
期刊论文数量(30)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Tekeshi Hanazawa: "Efficient and Practical Method for Synthesizing Optically Active Indan-2-ols by the Ti(O-i-Pr)_4/2 i-PrMgCl-Mediated Metalative Reppe Reaction"J.Org.Chem.. 68. 4980-4983 (2003)
Tekeshi Hanazawa:“通过 Ti(O-i-Pr)_4/2 i-PrMgCl 介导的金属 Reppe 反应合成光学活性茚满-2-醇的高效实用方法”J.Org.Chem.. 68. 4980-4983 (
- DOI:
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- 影响因子:0
- 作者:
- 通讯作者:
Yongcheng Song: "An efficient synthesis of optically active five- and six-membered cyclic compounds with selectable stereo-controls by a Ti(II)-mediated cyclization of chiral secondary 2,7- and 2,8-enyn-1-ol derivatives"Tetrahedron Lett.. 44. 653-657 (200
宋永成:“通过 Ti(II) 介导的手性二级 2,7- 和 2,8-enyn-1-ol 衍生物的环化,有效合成具有选择性立体控制的光学活性五元和六元环状化合物
- DOI:
- 发表时间:
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- 影响因子:0
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- 通讯作者:
Yuuki Takayama: "Efficient and General Synthetic Method for Preparing Oligoenynes with Either Trans- or cis-Olefinic Configuration"Org.Lett.. 5. 365-368 (2003)
Yuuki Takayama:“制备具有反式或顺式烯烃构型的寡烯的高效通用合成方法”Org.Lett.. 5. 365-368 (2003)
- DOI:
- 发表时间:
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- 影响因子:0
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Highly Practical and General Synthesis of Monodisperse Linear π-Conjugated Oligoenynes and Oligoenediynes with Either trans-or cis-Olefin Configuration
具有反式或顺式烯烃构型的单分散线性 π-共轭低烯和低烯二炔的高度实用和通用合成
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:Yuuki Takayama
- 通讯作者:Yuuki Takayama
An Efficient Synthesis of Optically Active (2R,3R)-2-Methyl-3-[(1R)-1-methylprop-2enyl] Cyclopentanone, a Useful Chiral Building Block for Synthesis of Vitamin D and Steroids
光学活性 (2R,3R)-2-甲基-3-[(1R)-1-甲基丙-2烯基]环戊酮的高效合成,这是一种用于合成维生素 D 和类固醇的有用手性结构单元
- DOI:
- 发表时间:2003
- 期刊:
- 影响因子:0
- 作者:M.Suzuki;R.Taniguchi;A.Osuka;Yongcheng Song
- 通讯作者:Yongcheng Song
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{{ truncateString('SATO Fumie', 18)}}的其他基金
Practical Synthetic Reactions for Tine Chemical Using a Divalent Titanium Reagent
使用二价钛试剂进行锡化学品的实际合成反应
- 批准号:
12450359 - 财政年份:2000
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of an efficient method for synthesizing N-heterocyclic compounds based on a divalent titanium complex
开发基于二价钛配合物的高效合成N-杂环化合物的方法
- 批准号:
09555284 - 财政年份:1997
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Direct synthetic method for preparation of organotitanium complexes and their synthetic utility
制备有机钛配合物的直接合成方法及其合成用途
- 批准号:
07455359 - 财政年份:1995
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for Scientific Research (B)
Development of practical synthetic method for preparation of alcohols in chiral from.
开发用于制备手性醇的实用合成方法。
- 批准号:
05650871 - 财政年份:1993
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)
Development of a General Method for Synthesis of Optically Active Tertiarv Allylic Alcohols and Its Applications
光学活性叔烯丙醇合成通用方法的建立及其应用
- 批准号:
02453091 - 财政年份:1990
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for General Scientific Research (B)
Acyclic stereoselection using 1, 2-diastereoselective induction reactions
使用 1, 2-非对映选择性诱导反应进行非环状立体选择
- 批准号:
62550623 - 财政年份:1987
- 资助金额:
$ 9.22万 - 项目类别:
Grant-in-Aid for General Scientific Research (C)