Measurement and analysis of language functions in the frontal regions using magnetoencephalography and functional magnetic resonance imaging

使用脑磁图和功能磁共振成像测量和分析额叶区域的语言功能

• 批准号: 15500307
• 负责人: TAKEUCHI Fumiya
• 金额: $ 1.6万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15500307/
• 关键词: MEG; fMRI; letters; speech sounds; frequency analysis; time frequency analysis; wavelet

In this research, we measured and analyzed the language function in the frontal regions using magnetic imaging techniques. This research was composed of four sections : (1)improvement in measurement and analysis techniques of MEG, (2)establishment of the time-frequency analysis method, (3)construction of language tasks that induce fMRI activation in the frontal regions, (4)measurement and analysis of the language function in the frontal regions using MEG. This report mainly presents the results of section (4)since sections (1)-(3) are fundamental researches for section (4).In an MEG measurement, subjects were instructed to perform a word categorization task that evoked cortical activities in an fMRI study. The MEG responses were analyzed using dipole source analysis, frequency analysis, and time-frequency analysis. In the dipole source analysis, almost all the dipoles were localized in the temporal regions, while only a few dipoles were localized in, the frontal regions. However, in the frequency and tune-frequency analysis, magnetic responses were observed in the temporal and frontal regions. The alpha band amplitude was remarkable in the temporal regions while the delta band amplitude was distinctive in the frontal regions. This result showed that neurons in the temporal and frontal regions were activated by the language task. Desynchronization of the alpha band MEG in the temporal regions was observed for one of the subjects. This does not indicate the correlation of neural activities with a magnitude of the alpha band.The results suggested that neural activities evoked by language tasks were found in the frontal regions, and these activities were related to the delta band MEG. Therefore, neural activities during language tasks may hardly synchronize with task onsets in the frontal regions.

本研究利用磁成像技术对额叶语言功能进行了测量和分析。本研究包括四个部分：（1）脑磁图测量和分析技术的改进，（2）时频分析方法的建立，（3）诱发额叶功能磁共振成像激活的语言任务的构建，（4）脑磁图对额叶语言功能的测量和分析。由于第（1）-（3）部分是第（4）部分的基础研究，因此本报告主要介绍第（4）部分的结果。在脑磁图测量中，被试被要求执行一个词分类任务，在功能磁共振成像研究中诱发皮层活动。采用偶极子源分析、频率分析和时频分析对脑磁图进行分析。在偶极子源分析中，几乎所有的偶极子都位于颞区，而只有少数偶极子位于额区。然而，在频率和调谐频率分析中，在颞区和额区观察到磁响应。α波振幅在颞区显著，而δ波振幅在额区显著。这一结果表明，颞叶和额叶的神经元被语言任务激活。其中一名受试者在颞区观察到α带MEG的去极化。这并不表明神经活动与α带幅度的相关性。结果表明，语言任务引起的神经活动在额叶区，这些活动与δ带MEG有关。因此，语言任务中的神经活动可能很难与额叶区域的任务启动同步。

项目成果

MEG responses form the frontal regions using a whole head SQUID system

使用整个头部 SQUID 系统形成额叶区域的 MEG 响应

• 发表时间: 2004
• 期刊: Proceedings of the 14 th International Conference on Biomagnetism
• 作者: M.Sakae;Y.Koyama et al.;K.Maruyama Y.Koyama et al.;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Tomoko Ito;Yoshiyuki Koyama;F.Takeuchi
• 通讯作者: F.Takeuchi

MEG signals from subjects lying prone in a whole head SQUID magnetometer

来自全头 SQUID 磁力计中俯卧受试者的 MEG 信号

• 发表时间: 2004
• 期刊: The Journal of Japan Biomagnetism and Bioelectromagnetics Society 17
• 作者: M.Sakae;Y.Koyama et al.;K.Maruyama Y.Koyama et al.;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Tomoko Ito;Yoshiyuki Koyama;F.Takeuchi;K.Kamada;S.Kuriki;N.Tanaka;H.Aoyama;K.Kamada;竹内文也;竹内文也;F.Takeuchi;F.Takeuchi
• 通讯作者: F.Takeuchi

Gradual recovery from dyslexia and related serial magnetoencephalographic changes in the lexicosemantic centers after resection of a mesial temporal astrocytoma

颞叶内侧星形细胞瘤切除后，词汇语义中心的阅读障碍和相关系列脑磁图变化逐渐恢复

• 发表时间: 2004
• 期刊: J Neurosurg 100・6
• 作者: M.Sakae;Y.Koyama et al.;K.Maruyama Y.Koyama et al.;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Tomoko Ito;Yoshiyuki Koyama;F.Takeuchi;K.Kamada;S.Kuriki;N.Tanaka;H.Aoyama;K.Kamada
• 通讯作者: K.Kamada

竹内文也ほか: "全頭型SQUlD磁束計におけるうつぶせ姿勢によるMEG計測"日本生体磁気学会誌. (印刷中). (2004)

Fumiya Takeuchi 等人：“使用全头 SQUlD 磁力计进行俯卧位 MEG 测量”，日本生物磁学会杂志（2004 年出版）。

Identification of the eloquent motor cortex using magnetic resonance axonography, MEG and fMRI

使用磁共振轴突扫描、脑磁图和功能磁共振成像识别口才运动皮层

• 发表时间: 2004
• 期刊: Proceedings of the 14 th International Conference on Biomagnetism
• 作者: M.Sakae;Y.Koyama et al.;K.Maruyama Y.Koyama et al.;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Yoshiyuki Koyama;Tomoko Ito;Yoshiyuki Koyama;F.Takeuchi;K.Kamada
• 通讯作者: K.Kamada