A cardiopathological study on the anatomical substrate for fatal arrhythmias in aged companion animals

老年伴侣动物致命性心律失常解剖学基础的心脏病学研究

基本信息

项目摘要

The cardiac conduction system was histologically examined in 11 feline cases and 4 canine cases of complete atrioventricular block(CAVB) with the serial sectioning method and the following results and conclusions were obtained. In the cats with CAVB, underlying diseases included 9 cases of hypertrophic cardiomyopathy and each one case of mitral valve dysplasia and severe cardiac hypertrophy secondary to chronic interstitial nephritis. Histologically, a chondroid-or osseous-metaplastic lesion was seen in the lowermost portion of the fibrosed central fibrous body, protruding downward to the interventricular septal crest in each case. The lesion had compressed the penetrating portion and/or branching portion of the bundle of His, causing various degrees of degenerative changes and lysis and marked fibrosis of the bundle fibers. The marked fibrosis of the central fibrous body with cartilage or bone formation seems to occur as a result of stress and strain on the fibrous skeleton of the heart and may be due to mechanical factors created by hypertrophy of the interventricular septum. In all the 4 dogs with CAVB, gross anatomic changes associated with conduction system abnormalities included valvular endocardiosis of both atrioventricuar valves and endocardial fibrosis of the uppermost interventricular septum. Histologically, moderate to severe reduction of the conducting cells due to fibrous or fibro-fatty replacement was observed in some level in the penetrating and/or branching portions of the bundle of His in each case. In addition, 3 cases among the 4 had coexisting lesions at the proximal portions of the both bundle branches. This type of block in dogs was due to involvement of the conduction system in pathologic processes of the central fibrous body resulting from extension of myxomatous degeneration of both atrioventricular valves.
本文用连续切片法对11例猫和4例犬完全性房室传导阻滞(CAVB)的心脏传导系统进行了组织学检查。在CAVB猫中,基础疾病包括9例肥厚性心肌病和各1例二尖瓣发育不良和继发于慢性间质性肾炎的严重心脏肥大。在组织学上,在纤维化的中央纤维体的最下部可见软骨样或骨化生病变,在每种情况下向下突出到室间隔嵴。病变压迫了希氏束的穿透部分和/或分支部分,引起不同程度的退行性变化和纤维溶解,并使束纤维明显纤维化。具有软骨或骨形成的中央纤维体的显著纤维化似乎是由于心脏纤维骨架上的应力和应变而发生的,并且可能是由于室间隔肥大产生的机械因素。在所有4只CAVB犬中,与传导系统异常相关的大体解剖学改变包括两个房室瓣的瓣膜性心内膜病和最上部室间隔的内膜纤维化。在组织学上,在每种情况下,在His束的穿透和/或分支部分的一定水平上观察到由于纤维或纤维脂肪替代导致的传导细胞的中度至重度减少。4例中3例同时存在双束支近端病变。犬的这种类型的阻滞是由于传导系统参与了由两个房室瓣粘液瘤变性扩展引起的中央纤维体的病理过程。

项目成果

期刊论文数量(8)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
A histopathological study of the cardiac conduction system in a heifer with complete atrioventricular block
完全性房室传导阻滞小母牛心脏传导系统的组织病理学研究
Clinicopathological correlations between cardiac arrhythmias And histopathology of the conduction system
心律失常与传导系统组织病理学之间的临床病理学相关性
町田 登: "不整脈の病理 -不整脈死例の心臓刺激伝導系病変を中心に-"SA Medicine (Journal of Small Animal Medicine). 5・2. 12-18 (2003)
Noboru Machida:“心律失常的病理学 - 关注致命心律失常病例中的心脏传导系统病变”SA Medicine(小动物医学杂志)5·2(2003)。
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A histological study of the cardiac conduction system in a heifer with complete atrioventricular block
完全性房室传导阻滞小母牛心脏传导系统的组织学研究
不整脈の病理-心臓刺激伝導系病変を中心に-
心律失常的病理学 - 关注心脏传导系统的病变 -
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MACHIDA Noboru其他文献

MACHIDA Noboru的其他文献

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{{ truncateString('MACHIDA Noboru', 18)}}的其他基金

A clinicopathological study on diagnostic techniques for malignant mesothelioma in dogs and cats
犬、猫恶性间皮瘤诊断技术的临床病理学研究
  • 批准号:
    17580278
  • 财政年份:
    2005
  • 资助金额:
    $ 0.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Quantitative structural analysis of athletic hearts of racing pigeons
赛鸽运动心脏的定量结构分析
  • 批准号:
    12660282
  • 财政年份:
    2000
  • 资助金额:
    $ 0.7万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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