Quantitative analysis of the arterial baroreflex transient response during acute myocardial infarction toward optimized therapy

急性心肌梗死期间动脉压力反射瞬态反应的定量分析以优化治疗

• 批准号: 15590786
• 负责人: KAWADA Toru
• 金额: $ 1.79万
• 依托单位: National Cardiovascular Center Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15590786/
• 关键词: acute myocardial infarction; arterial baroreflex; transfer function; equilibrium diagram; coronary occlusion; sympathetic nerve activity; circulatory model; circulatory control; ベツオルド-ヤーリッシュ反射

The present study was designed to quantitatively analyze the effects of acute myocardial infarction on the cardiovascular regulation and to develop a circulatory model capable of describing hemodynamic changes during acute myocardial infarction. By using this model, hemodynamic changes during acute myocardial infarction may be described quantitatively in terms of changes in model parameters. Such a quantitative evaluation would contribute to a risk stratification of acute myocardial infarction. In addition, the prediction of the circulatory responses to drug administrations would lead to the optimized drug administrations with tide minimum total amount of drug used. In the present study, we quantified the dynamic and static characteristics of the arterial baroreflex by a transfer function analysis and an equilibrium diagram analysis, respectively. In anesthetized rabbits, activation of the vagally-mediated cardiac reflex by phenylbiguanide approximately halved the arterial baroreflex g … More ain calculated from changes in sympathetic nerve activity relative to the pressure changes. We designed an automated drug infusion system by taking into account the predicted changes in the baroreflex gain. When a classical proportional-integrative-derivative(PID) controller with fixed parameter values was used, changes in the magnitude of biological responses to a given amount of drug makes the circulatory regulation unstable. In contrast, an adaptive predictive controller with a neural network provided a stable circulatory regulation regardless of changes in the biological responses to a given amount of drug. Although the effects of acute coronary occlusion on the arterial baroreflex were examined, changes in the dynamic characteristics were not significant even when hypotension with pump failure manifested. Possible explanation for the absence of significant effects of coronary occlusion on the baroreflex gain might be an absence of vagally-mediated cardiac reflex due to vagal withdrawal under anesthetic conditions. Less

本研究旨在定量分析急性心肌梗死对心血管调节的影响，并建立一个能够描述急性心肌梗死时血流动力学变化的循环模型。利用该模型，可以定量地描述急性心肌梗塞时的血流动力学变化。这样的定量评估将有助于急性心肌梗死的危险分层。此外，对药物给药的循环反应的预测将导致具有最小药物使用总量的优化药物给药。在本研究中，我们量化的动态和静态特性的动脉压力感受器反射的传递函数分析和平衡图分析，分别。在麻醉家兔中，苯双胍激活迷走神经介导的心脏反射使动脉压力感受性反射约减半。 ...更多信息 ain由交感神经活动相对于压力变化的变化计算。我们设计了一个自动药物输注系统，考虑到压力反射增益的预测变化。当使用具有固定参数值的经典比例-积分-微分（PID）控制器时，对给定量药物的生物反应幅度的变化使循环调节不稳定。相比之下，具有神经网络的自适应预测控制器提供了稳定的循环调节，而不管对给定量药物的生物反应的变化。虽然急性冠状动脉闭塞对动脉压力感受性反射的影响进行了检查，动态特性的变化并不显着，即使低血压与泵衰竭表现。冠状动脉闭塞对压力反射增益无显著影响的可能解释可能是麻醉条件下迷走神经撤回导致迷走神经介导的心脏反射缺失。少

项目成果

A self-calibrating telemetry system for measurement of ventricular pressure-volume relations in conscious, freely moving rats

• DOI: 10.1152/ajpheart.00035.2004
• 发表时间: 2004-12-01
• 期刊: AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
• 影响因子: 4.8
• 作者: Uemura, K;Kawada, T;Sunagawa, K
• 通讯作者: Sunagawa, K

Effects of neuronal norepinephrine uptake blockade on baroreflex neural and peripheral arc transfer characteristics.

神经元去甲肾上腺素摄取阻断对压力反射神经和外周弧传递特征的影响。

• 发表时间: 2004
• 期刊: Am J Physiol Regul Integr Comp Physiol. 286
• 作者: 近藤智靖;高橋健夫;岡出美則;Kawada T et al.
• 通讯作者: Kawada T et al.

Muscle mechanoreflex induces the pressor response by resetting the arterial baroreflex neural arc.

肌肉机械感受通过重置动脉压力感受神经弧来诱导升压反应。

• 发表时间: 2004
• 期刊: Am J Physiol Heart Circ Physiol. 286
• 作者: Inadama;N.;Murayama;H.;Watanabe;M.;Omura;T.;Yamashita;T.;Kawai;H.;Umehara;T.;Kasahara;T.;Orita;N.;Tsuda;T.;Yamamoto K et al.
• 通讯作者: Yamamoto K et al.

Uemura K: "A novel framework of circulatory equilibrium"Am J Physiol Heart Circ Physiol. (in press). (2004)

Uemura K：“循环平衡的新颖框架”Am J Physiol Heart Circ Physiol。

Kashihara K: "Bezold-Jarisch reflex attenuates dynamic gain of baroreflex neural arc"Am J Physiol Heart Circ Physiol. 285・2. H833-H840 (2003)

Kashihara K：“Bezold-Jarisch 反射减弱压力反射神经弧的动态增益”Am J Physiol Heart Circ Physiol 285・2。