The effect of gefinitb (Iressa) on radiation of lung-analysis of anti-cancer effect and radiation pneumonia

吉非替尼（易瑞沙）对肺部辐射的影响——抗癌作用及放射性肺炎分析

基本信息

批准号：
15591262
负责人：
ONISHI Hiroshi
金额：
$ 2.37万
依托单位：
University of Yamanashi
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2006
项目状态：
已结题

项目摘要

We conducted the respiratory function determination, pulmonary function determination, blood biochemistry and histological study in irradiated rats, and studied the effect of irradiation on their respiratory and pulmonary functions.Rats were divided into the following four groups; 25Gy left lung irradiation group, 17Gy bilateral lung irradiation group, 20Gy bilateral lung irradiation group and 25Gy bilateral lung irradiation group. The rats, having had their lungs irradiated in the Yamanashi University School of Medicine, were accepted in this research institute. We determined the body weight, body temperature and respiratory function every week and conducted pulmonary function determination, measurement of differential leukocyte counts of bronchoalveolar lavage fluid (BALF), arterial blood gas analysis, hematology, blood biochemistry and histopathological study every two weeks.Based on the results, changes in respiratory function, pulmonary function, hematological parameters, differen … More tial leukocyte counts of BALF and pulmonary fibrosis were confirmed following the irradiation of lungs in rats. To study the therapeutic effect of drugs on these irradiation-linked changes, a study conducted 6-8 weeks after irradiation including the 20Gy bilateral lung irradiation group, among the 25Gy left lung irradiation, 17Gy bilateral lung irradiation, 20Gy bilateral lung irradiation, and 25Gy bilateral lung irradiation groups, may be suitable.Next, we administrated 5 days of gefinitib(50mg/kg/body weight) and/or once cisplatin(10mg/kg/body weight) just before irradiation of 20Gy for bilateral rat lungs. The lung inflammation and fibrosis was increased by the administration of gefinitib and more by the addition of cisplatin in the findings of physiological pulmonary function and histopathology.In conclusion, a study conducted 6-8 weeks after irradiation including the 20Gy bilateral lung irradiation is a good model for a evaluation of a drug effect on rat radiation lung interstitial change, and we have to pay attention to the addition of gefinitib and/or cisplatin to lung radiotherapy. Less

我们在辐照大鼠中进行了呼吸功能测定，肺功能测定，血液生物化学和组织学研究，并研究了辐照对其呼吸和肺功能的影响。将大鼠分为以下四组。 25GY左肺辐照组，17GY双侧肺辐照组，20GY双侧肺辐照组和25GY双侧肺辐照组。这位研究所接受了在Yamanashi大学医学院被辐照的肺部的老鼠。 We determined the body weight, body temperature and respiratory function every week and conducted pulmonary function determination, measurement of differential leukocyte counts of bronchoalveolar lavage fluid (BALF), arterial blood gas analysis, hematology, blood biochemistry and histopathological study every two weeks.Based on the results, changes in respiratory function, pulmonary function, hematologic parameters, different … More tial leukocyte在大鼠肺部照射后，证实了BALF和肺纤维化的数量。为了研究药物对这些辐射连接变化的治疗作用，一项在辐射后6-8周进行的一项研究，包括20GY双侧肺辐照组，在25Gy的左肺辐射中，17GY双侧肺辐照，20型双侧双侧肺辐射，以及25次双侧双侧辐射组，可能是适当的，可能是5天，以至于以下合适的肺部，以至于以为以至于以为以至于以至于以为以至于以为以至于以至于以为以至于以为我们是5天，以至于以至于以为我们是5天。 geffinitib（50mg/kg/体重）和/或一次顺铂（10mg/kg/体重）在对双侧大鼠肺的20GY辐射之前。通过在物理肺功能和组织病理学的发现中，通过geffinitib的给药以及增加顺铂增加了肺注射和纤维化。顺铂至肺放疗。较少的