Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape (P05)

白血病干细胞癌基因驱动的腺苷产生促进其免疫逃逸 (P05)

• 批准号: 464626686
• 金额: --
• 依托单位: Max-Planck-Institut für Immunbiologie und Epigenetik
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/464626686?language=en
• 关键词: Oncogene; driven; adenosine; production; leukaemic

Leukaemic stem cells (LSCs) are often associated with leukaemia burden as well as relapses. Our preliminary data show that oncogenic signalling induces adenosine production in AML LSCs which can be a key mechanism to facilitate their immune escape. Our project aims to address how oncogene-driven adenosine and other metabolites production by LSCs inhibits immune cell function, such as antigen presentation by resident macrophages, and promotes LSC-quiescence, which is by itself an immune escape mechanism. The ultimate goal is to find new therapeutic avenues to potentially circumvent immune escape of LSCs.

白血病干细胞（LSC）通常与白血病负荷以及复发相关。我们的初步数据表明，致癌信号诱导AML LSC中腺苷的产生，这可能是促进其免疫逃逸的关键机制。我们的项目旨在解决LSC产生的癌基因驱动的腺苷和其他代谢产物如何抑制免疫细胞功能，例如常驻巨噬细胞的抗原呈递，并促进LSC静止，这本身就是一种免疫逃逸机制。最终目标是找到新的治疗途径，以潜在地规避LSC的免疫逃逸。