Oncogene-driven adenosine production by leukaemic stem cells promotes their immune escape (P05)

白血病干细胞（LSC）通常与白血病负荷以及复发相关。我们的初步数据表明，致癌信号诱导AML LSC中腺苷的产生，这可能是促进其免疫逃逸的关键机制。我们的项目旨在解决LSC产生的癌基因驱动的腺苷和其他代谢产物如何抑制免疫细胞功能，例如常驻巨噬细胞的抗原呈递，并促进LSC静止，这本身就是一种免疫逃逸机制。最终目标是找到新的治疗途径，以潜在地规避LSC的免疫逃逸。

Leukaemic stem cells (LSCs) are often associated with leukaemia burden as well as relapses. Our preliminary data show that oncogenic signalling induces adenosine production in AML LSCs which can be a key mechanism to facilitate their immune escape. Our project aims to address how oncogene-driven adenosine and other metabolites production by LSCs inhibits immune cell function, such as antigen presentation by resident macrophages, and promotes LSC-quiescence, which is by itself an immune escape mechanism. The ultimate goal is to find new therapeutic avenues to potentially circumvent immune escape of LSCs.