Continuous estimation of blood concentration of substances using photo-technology

使用光学技术连续估算血液中物质浓度

基本信息

  • 批准号:
    15591622
  • 负责人:
  • 金额:
    $ 2.24万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
  • 财政年份:
    2003
  • 资助国家:
    日本
  • 起止时间:
    2003 至 2005
  • 项目状态:
    已结题

项目摘要

The purpose of this project was to estimate blood concentrations of various substances using fibre-optic catheter in combination with advanced photo-technology.1.Producing an optical instrumentThis optical instrument that is able to supply and receive eight kinds of wavelengths of light, was designed for the Abbott fibre-optic catheters. This multi wavelengths optical instrument enabled to measure light absorption and fluorescence of intra-blood substances.2.Searching intra-blood substancesWe investigated several intravenous agents and native substances in vitro as candidates of the subjects in this project.1)Light absorbentWe studied indocyanin green (ICG), indigo carmine, sulphonate carbachrom, and glucose as light absorbents. Among them ICG was the most suitable for this measurement. Although glucose did not absorb any wavelength of visible light, its absorption spectrum was slightly different from that of water in near infrared.2)FluorescentWe studied riboflavin and propofol as fluorescents. Intensity of the fluorescence correlated to the concentration of riboflavin. Propofol in plasma did not emit fluorescence because of protein binding.3.In vitro studyRelationship between ICG concentration and the fluorescence intensity was studied in blood samples in a tube. The relationship between ICG concentration and the fluorescence intensity was linear up to 3 μg/ml, and this relationship was almost same in the three blood samples of different haemoglobin concentrations.4.In vivo studyNew Zealand White rabbits were studied. A 5.5 Fr Abbott fibre-optic catheter was inserted from right jugular vein. The tip of catheter was placed at three positions ; superior vena cava, right atrium and inferior vena cava, and recorded 830 nm signal output at each position. At the position of the minimum noise 5 mg of ICG was injected. The 5 mg of ICG injected intravenously provided sufficient intensity of 830 nm fluorescence signal.
本项目的目的是利用光纤导管结合先进的光学技术来估计血液中各种物质的浓度。生产一种光学仪器这种光学仪器能够提供和接收八种波长的光,是为雅培光纤导管设计的。这种多波长光学仪器能够测量血液内物质的光吸收和荧光。寻找血内物质我们调查了几种静脉注射药物和体外天然物质作为本项目的候选对象。1)光吸收:我们研究了吲哚花青素绿(ICG)、靛蓝胭脂红、磺酸碳蓝和葡萄糖作为光吸收剂。其中,ICG是最适合这种测量的。葡萄糖虽然不吸收任何波长的可见光,但其在近红外波段的吸收光谱与水略有不同。我们研究了核黄素和异丙酚作为荧光剂。荧光强度与核黄素浓度相关。血浆中异丙酚因蛋白结合而不发出荧光。体外实验研究了试管血液中ICG浓度与荧光强度的关系。在3 μg/ml以内,ICG浓度与荧光强度呈线性关系,且这种关系在不同血红蛋白浓度的3份血样中基本相同。对新西兰大白兔进行了体内研究。从右颈静脉插入5.5 Fr Abbott光纤导管。导管尖端放置于3个位置;上腔静脉、右心房和下腔静脉,记录每个位置830nm的信号输出。在噪声最小的位置注射ICG 5 mg。静脉注射ICG 5 mg,荧光信号强度达到830 nm。

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Estimation of intra-blood substance concentrations using photo-technology.
使用光学技术估计血液内物质浓度。
Photo-technology in anaesthesia and intensive care
麻醉和重症监护中的光学技术
エバネッセントカテーテルシステム
消失导管系统
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
インドシアニングリーン定量カテーテルシステム
吲哚菁绿定量导管系统
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
Detection of fluorescence in blood using fibre-optic catheter
使用光纤导管检测血液中的荧光
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DOI Matsuyuki其他文献

DOI Matsuyuki的其他文献

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{{ truncateString('DOI Matsuyuki', 18)}}的其他基金

Development of automatic infusion systems for sedatives and analgesics with surface EEGs and Auditory Evoked Potentials as Input Signals
开发以表面脑电图和听觉诱发电位作为输入信号的镇静镇痛药自动输注系统
  • 批准号:
    12671462
  • 财政年份:
    2000
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

相似海外基金

Estimation of intra-blood substance concentration using evanescent wave fluorescence
使用倏逝波荧光估计血液内物质浓度
  • 批准号:
    19591785
  • 财政年份:
    2007
  • 资助金额:
    $ 2.24万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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