The role of HRAS downstream signalling for the production of immunosuppressive metabolites in the microenvironment of HRAS-driven SCC (P13)

HRAS 下游信号传导在 HRAS 驱动的 SCC 微环境中产生免疫抑制代谢物的作用 (P13)

• 批准号: 464634844
• 金额: --
• 依托单位: Klinik für Dermatologie und Venerologie
• 依托单位国家: 德国
• 项目类别: Collaborative Research Centres
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/464634844?language=en
• 关键词: role; HRAS; downstream; signalling; production

Activating HRAS mutations occur frequently in cutaneous squamous cell carcinomas (cSCCs). Their impact on immune modulation remains poorly defined. Using mouse models and human tumour material, we will address how HRAS activation in cSCCs mediates immune evasion. Our aims are: 1. to understand the immune modulatory actions of HRAS; 2. to evaluate combined targeting of HRAS, EGFR and immunosuppressive metabolites and 3. to investigate T cell exhaustion in high-risk cSCCs and its relation to HRAS mutations. Collectively, the combined knowledge obtained from these aims will be translated into improved and personalized treatment for high-risk cSCCs.

激活HRAS突变在皮肤鳞状细胞癌(CSCCs)中频繁发生。它们对免疫调节的影响仍不清楚。使用小鼠模型和人类肿瘤材料，我们将解决cSCCs中HRAS激活如何介导免疫逃避。我们的目标是：1.了解HRAS的免疫调节作用；2.评价HRAS、EGFR和免疫抑制代谢物的联合靶向；3.研究高危CSCC中T细胞的耗竭及其与HRAS突变的关系。总体而言，从这些目标获得的综合知识将转化为对高危慢性鳞状细胞癌的改进和个性化治疗。