A study of sentinellymph nodes for malignant tumor of Head and Neck

前哨淋巴结（SLN）被称为恶性肿瘤原发部位的第一个或多个淋巴结。最近，SLN活检常用于早期恶性黑色素瘤（MM）患者。在本文中，7例MM，我们已经确定并检查了SLN在目前两年内显示。SLN是通过蓝色染料、淋巴显像和伽马探针技术定位的，除了两个病例我们单独用蓝色染料确定了SLN。通过组织病理学分析和RT-PCR检查切除的SLN是否存在转移。7例中有2例在两种检查中都发现了SLN的微转移。我们将详细描述这两种情况。在我们的7例病例中，两种检查结果均无差异。我们认为对日本早期MM患者的SLN进行鉴别和检查是有意义的。此外，由于淋巴管从原发病灶到区域淋巴结的距离较短，头颈部恶性肿瘤存在手工技术上的问题，即原发病灶内不易发现前哨淋巴结，且有大量影像接近前哨淋巴结。经过对RI胶体直径的检查，我认为99mTc-phytate是最合适的。此外，在剂量、注射时间-成像方面，笔者考察了一种成像方法。

The sentinel lymph node (SLN) is known as the first node or nodes to drain the primary site a malignant neoplasm. Recently, the biopsy of SLN has often been performed for patients with early stages of malignant melanoma (MM). In this paper, seven cases of MM that we have identified and examined SLN during current two years are shown. SLN was localized with the techniques of blue dye, lymphoscintigraphy, and a gamma probe, except for two cases we identified SLN with blue dye alone. The presence of metastases in excised SLN was examined by the histopathologic analysis and RT-PCR procedure. Micrometastases in SLN were detected in two out of seven cases by both examinations. We describe these two cases in detail. No different result between both examinations was found in our seven cases. We believe that it should be significant to identify and examine SLN of Japanese patients with early stages of MM. In addition, distance of lymphatic vessel from primary lesion to regional lymph node was short, and, in a head and neck malignant tumor, there was a problem of a manual skill that a sentinel lymph node was hard to be detected in a primary lesion and case a lot of images that approached it. As a result of having examined RI colloid diameter, I understood that 99mTc-phytate was most suitable. Furthermore, in the dose, time to injection - imaging, I examined an imaging method.