Development of safety and general purpose conduction anesthesia and appreciation to the trigeminal area

安全和通用传导麻醉的发展以及对三叉神经区的认识

• 批准号: 15592100
• 负责人: KOHASE Hikaru
• 金额: $ 2.24万
• 依托单位: Tokyo Medical and Dental University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-15592100/
• 关键词: Induced electrical field; Conduction block; Frequency dependent; Voltage dependent; 持続型神経ブロック; 腋窩神経ブロック

The facilitating local anesthetic diffusion in subcutaneous tissue by AC induced electrical field and the appearance conduction block were investigated in this study.The disappearance of c-fiber with administration of 0.3ml of 2%lidocaine at adjacent of femoral nerve was defined the success of femoral conduction block. The effects of passive diffusion and active diffusion (adding AC induced electrical field) to the efficacy of conduction block were investigated. The shortage of onset of conduction block were existed as voltage dependent manner in induced electrical field at the constant frequency of 10kHz, and the frequency dependent manner at the constant 10 mV voltage stimulation.These results suggested that the AC induced electrical field contribute to the facilitation of conduction block.

本研究探讨了交流感应电场促进局麻药在皮下组织扩散和出现传导阻滞的作用。在股神经邻近部位给予2%利多卡因0.3ml， c纤维消失即为股神经传导阻滞成功。研究了被动扩散和主动扩散（外加交流感应电场）对传导阻滞效果的影响。在恒定频率为10kHz的感应电场中，传导阻滞的发生以电压依赖的方式存在，在恒定10mv电压刺激下，传导阻滞的发生以频率依赖的方式存在。这些结果表明，交流感应电场有助于促进传导阻滞。

项目成果

Hikaru Kohase et al.: "Decrease BIS index as indicator of syncope before hypotensioin and bradycardia in two patients with needle phobia."British Journal of Anaesthesia. 91(5). 749-752 (2003)

Hikaru Kohase 等人：“在两名针恐惧症患者出现低血压和心动过缓之前，降低 BIS 指数作为晕厥的指标。”《英国麻醉杂志》。

Allergic Reaction to Epinephrine Preparation in 2%Lidocaine : Two Case Reports.

过敏%20反应%20至%20肾上腺素%20制剂%20in%202%利多卡因%20：%20两个%20病例%20报告。

• 发表时间: 2004
• 期刊: Anesthesia Progress 51
• 作者: Kohase H;Umino M
• 通讯作者: Umino M

Hikaru Kohase: "Application of mandibular nerve block using an indwelling catheter for intractable cancer pain."Acta Anaesthesiol Scand. in printing. (2004)

Hikaru Kohase：“使用留置导管应用下颌神经阻滞治疗顽固性癌症疼痛。”Acta Anaesthesiol Scand。

Hikaru Kohase, et al.: "Endotracheal intubation deveice with a charge couple device camera."Anesthesia and Analgesia. 96. 432-434 (2003)

Hikaru Kohase 等人：“带有电荷耦合装置摄像头的气管插管装置。”麻醉和镇痛。

Application of a mandibular nerve block using an indwelling catheter for intractable cancer pain.

使用留置导管应用下颌神经阻滞治疗顽固性癌痛。

• 发表时间: 2004
• 期刊: Acta Anaesthesiol Scand 48
• 作者: Kohase H;Umino M;Shibaji T;Suzuki N
• 通讯作者: Suzuki N