The Relationship between Breslow Score or Oral Health Score and Sister Chromatid Exchange (SCE) in Human Volunteer's Blood

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In recent years, there have been many studies conducted on genes, which shed light on the impact of people's lifestyle on gene defects. Recognizing the importance of people's lifestyle, there have also been several studies conducted on the relationship between lifestyle and general health conditions. This study was aimed at demonstrating the relationship between dental health or general health (Breslow score) and genes. In evaluating the dental health status, we used the Oral Healthiness Score developed by Morita et al. : we used questionnaires to obtain information about dental health status of the subjects. In investigating the presence of gene defect, the human peripheral lymphocyte culture devised by Morimoto et al. was used for the quantitative measurement of sister chromatid exchange (SCE) in blood samples collected from the subjects. The result of this study showed that there was a weak correlation between SCE and the score value of the Oral Healthiness Score (r=-0.30,p<0.05,contribution ratio of 8.98%). In other words, the higher subjects scored on the Oral Healthiness Score, the lower the SCE rate was, suggesting that people who have healthy lifestyle according to the Oral Healthiness Score tend to have fewer gene defects. However, there was no significant correction between Breslow's score and means of SCE(30), too (r=0.133).