Intervention study on effects of resistance training on endothelial function of middle and elder persons

抗阻训练对中老年人内皮功能影响的干预研究

• 批准号: 17590538
• 负责人: SAKAKIBARA Hisataka
• 金额: $ 2.37万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17590538/
• 关键词: Endothelium; Atherosclerosis; Resistance training; Middle and elder persons

Life-style related diseases are risk factors for atherosclerosis and cardiovascular diseases. Various health programs on diet and exercise have been tried for the prevention. The aim of the present study was to investigate the effects of resistance training on endothelial function of middle and elder persons. The present study was conducted as a randomized intervention study where resistance training was done for three months on the intervention group with 45 subjects. For the control group with 41 persons, health guidance based on health checkup was made. Body weight and west circumstance were moderately reduced in the intervention group, while they were slightly or little changed in the control group. Blood lipid and sugar levels were decreased in the intervention group, whereas they were not changed in the control groups. Acute inflammatory reactive proteins such as hs-CRP and plasma fibrinogen reduced in the intervention group more definitely than in the control groups. Von Willebrand factor, as an indicator of endothelial function, increased in both groups. The present study suggested that resistance training may improve inflammatory reaction related to atherosclerosis, which were represented by a reduction of hs-CRP and plasma fibrinogen However, von Willebrand factor need to be further investigated with respect to its appropriate indicator of endothelial function. NO measurement may be the alternative.

生活方式相关的疾病是动脉粥样硬化和心血管疾病的危险因素。人们已经尝试了各种关于饮食和锻炼的健康计划来预防这种疾病。本研究旨在探讨阻力训练对中老年人血管内皮功能的影响。本研究为随机干预研究，干预组对45名受试者进行为期3个月的阻力训练。对照组41人，在体检的基础上进行健康指导。干预组体重和西部环境呈中度下降，对照组变化不大或不明显。干预组血脂、血糖水平下降，而对照组无明显变化。干预组急性炎症反应蛋白如hs-CRP和血浆纤维蛋白原较对照组下降更明显。作为血管内皮细胞功能指标的von Willebrand因子在两组均升高。本研究提示抗阻训练可改善动脉粥样硬化相关的炎症反应，表现为hs-CRP和血浆纤维蛋白原的降低，但von Willebrand因子是否具有合适的内皮功能指标尚需进一步研究。没有任何衡量标准可能是替代方案。