Characteristics and standardization of cardiac function in elderly populations

为规范老年人心功能进行了以下工作。1)项目第一年在日本核医学学会（JSNM）组织了一个为期两年的工作组。在日本医科大学、庆应义塾大学、北海道大学、金泽大学、鸟之门医院、东宝大学成员的合作下，积累了心肌标准数据。这些项目由每个机构的伦理委员会批准。数据被传输到金泽大学中心办公室工作站的格式。在本次研究中，我们联系了常用心肌灌注定量软件的开发者Germano博士（Cedars Sinai Medical Center， USA）和Garcia博士（Emory University）。在这个项目的进展中，这种合作有效地发挥了作用。2)在2005年11月- 2007年10月JSNM工作组活动中，产生心肌灌注、脂肪酸代谢（1-123 BMIPP）和交感影像（1-123 MIBG）的标准数据。在资助期限内，我们完成了心肌灌注图的标准化工作。JSNM工作组的最终报告将作为JSNM活动的报告发布。3)生成心肌模型，验证1-123放射性药物的定量数据。数据采集采用标准模体，并针对不同类型的相机进行标准化。1-123放射性药物的多窗口采集方法是获得可靠数据的最佳实用选择。4)一项多中心研究，J-ACCESS （Nishimura, Tsunehiko，首席研究员）是日本核心脏病学领域的第一个预后研究。在本研究积累的4670例患者资料中，有268例受试者被选为冠状动脉疾病低危人群。当计算左心室射血分数和容积标准值时，男女之间以及不同年龄组之间存在显著差异。本研究强调了人群特异性标准的重要性。少

The following works have been performed for the standardization of the cardiac function in the elderly population.1)In the first year of this project, a two-year working group was organized in the Japanese Society of Nuclear Medicine (JSNM). By the cooperation of the members from Nihon Medical University, Keio-Gijuku University, Hokkaido University, Kanazawa University, Toranomon Hospital, Toho University, myocardial standard data were accumulated. The projects were approved by the ethical committees in each institution. The data were transferred to the format of the workstation in the center office of Kanazawa University. During this study, we took contact with Dr. Germano (Cedars Sinai Medical Center, USA) and Dr. Garcia (Emory University), who are the developer of the commonly available myocardial perfusion quantification software. The collaboration worked effectively in the progress of this project.2)In the JSNM working group activity, which has been performed from November 2005 to … More October 2007, standard data of myocardial perfusion, fatty acid metabolism (1-123 BMIPP) and sympathetic imaging (1-123 MIBG) were generated. By the deadline of the grants-in-aid, we finished the standardization of myocardial perfusion map. The final report from JSNM working group will be published as a report from the JSNM activity.3)Myocardial phantoms were generated and the quantitative data for 1-123 radiopharmaceutical was validated. The data acquisition was performed with the standard phantom, and standardized for the different types of cameras. Multiple-window acquisition method for 1-123 radiopharmaceutical was the best practical choice for the reliable data.4)A multi-center study, J-ACCESS (Nishimura, Tsunehiko, Chief investigator) was the first prognostic study in Japan in the field of Nuclear Cardiology. Among 4670 patients data accumulated for the study, 268 subjects were selected as the low-risk population for coronary artery disease. When standard values were calculated with respect to left ventricular ejection fraction and volumes, significant differences were demonstrated between female and male, and also among different age groups. Importance of population specific standard was emphasized by this study. Less