Characteristics and standardization of cardiac function in elderly populations

1)在该项目的第一年，日本核医学会(JSNM)组织了一个为期两年的工作组。通过来自日本医科大学、庆应义乌大学、北海道大学、金泽大学、东丽医院、东浩大学的成员的合作，积累了心肌标准数据。这些项目得到了每个机构的道德委员会的批准。将数据传输到金泽大学中心办公室的工作站格式。在这项研究中，我们联系了Germano博士(美国锡达斯西奈医学中心)和Garcia博士(埃默里大学)，他们是常用心肌灌注定量软件的开发者。2)在2005年11月至…期间开展的联合管理工作组活动中更多的2007年10月，产生了心肌血流灌注、脂肪酸代谢(1-123BMIPP)和交感神经显像(1-123MIBG)的标准数据。在助学金截止日期前，我们完成了心肌灌注图的标准化工作。JSNM工作组的最终报告将作为JSNM活动的报告发布。3)生成了心肌模型并验证了1-123放射性药物的定量数据。使用标准体模进行数据采集，并针对不同类型的相机进行标准化。4)多中心研究J-ACCESS(Nishimura，Tsunehiko，首席研究员)是日本在核心脏病领域的首个预后研究。在为研究积累的4670名患者数据中，268名受试者被选为冠心病的低危人群。当计算左心室射血分数和容量的标准值时，女性和男性之间以及不同年龄组之间也显示出显著差异。本研究强调了人群特异性标准的重要性。较少

The following works have been performed for the standardization of the cardiac function in the elderly population.1)In the first year of this project, a two-year working group was organized in the Japanese Society of Nuclear Medicine (JSNM). By the cooperation of the members from Nihon Medical University, Keio-Gijuku University, Hokkaido University, Kanazawa University, Toranomon Hospital, Toho University, myocardial standard data were accumulated. The projects were approved by the ethical committees in each institution. The data were transferred to the format of the workstation in the center office of Kanazawa University. During this study, we took contact with Dr. Germano (Cedars Sinai Medical Center, USA) and Dr. Garcia (Emory University), who are the developer of the commonly available myocardial perfusion quantification software. The collaboration worked effectively in the progress of this project.2)In the JSNM working group activity, which has been performed from November 2005 to … More October 2007, standard data of myocardial perfusion, fatty acid metabolism (1-123 BMIPP) and sympathetic imaging (1-123 MIBG) were generated. By the deadline of the grants-in-aid, we finished the standardization of myocardial perfusion map. The final report from JSNM working group will be published as a report from the JSNM activity.3)Myocardial phantoms were generated and the quantitative data for 1-123 radiopharmaceutical was validated. The data acquisition was performed with the standard phantom, and standardized for the different types of cameras. Multiple-window acquisition method for 1-123 radiopharmaceutical was the best practical choice for the reliable data.4)A multi-center study, J-ACCESS (Nishimura, Tsunehiko, Chief investigator) was the first prognostic study in Japan in the field of Nuclear Cardiology. Among 4670 patients data accumulated for the study, 268 subjects were selected as the low-risk population for coronary artery disease. When standard values were calculated with respect to left ventricular ejection fraction and volumes, significant differences were demonstrated between female and male, and also among different age groups. Importance of population specific standard was emphasized by this study. Less