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Cognitive function of breast cancer patients after adjuvant chemotherapy-Measurement by F-fluorodeoxyglucose positron emission tomography(FDG-PET)

乳腺癌患者辅助化疗后的认知功能——F-氟脱氧葡萄糖正电子发射断层扫描（FDG-PET）测量

基本信息

批准号：
17606002
负责人：
OHASHI Yasuo
金额：
$ 2.05万
依托单位：
The University of Tokyo
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2005
资助国家：
日本
起止时间：
2005 至 2006
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17606002/
关键词：
Breast Cancer Chemotherapy Cognitive impairment EDG-PET QOL

项目摘要

The purposes of this research are in the measurement of the cognitive function of breast cancer patients who receive adjuvant chemotherapy, the analysis of a change over time of the cognitive impairment, and the examination whether patient's cognitive impairment is related to a decrease in the function of the cranial nerve by using 18F-FDG-PET.A detailed research protocol and the questionnaire were made before the commencement of this research. Ethical Review Board of the Public Health Research Center, the Nihon University Itabashi Hospital and the Mitsui Memorial Hospital, examined them in terms of the invasiveness of PET examination and data confidentiality.The recruitment of female primary breast cancer patients who were able to be operated and had an adjuvant chemotherapy in the medical institutions started.There are two measurement points, before and one month after the neo-adjuvant chemotherapy. In each measurement point, we perform ; 1) an interview and clinical information coll … More ection, 2) questions on menstruation situation, 3) blood test and urine test, 4) general health condition check (ECOG-PSR), and 5) adverse events check (CTC). The patient himself answers, to ; 1) health-related QOL questionnaire (EORTC QLQ C-30), 2) cognitive function test (WAIS-R), and 3) depression state and mood disorders checklist (POMS), in front of the investigator as well. Afterwards, the patient is transported to the University of Tokyo Hospital, for imaging the brain function by PET.Another study with healthy women runs side by side with the examination on the breast cancer patient to confirm the learning effect of WAIS-R, and to adjust the measurement results. This measurement was performed to five healthy women of the same age group.The investigation results are collected from the medical institutions in the research office, and the research analysis is done on the data. The research protocol continues even after the end of the subvention period of the Grant-in aid for scientific research, increasing the number of medical institutions for recruitment of the patients, because enough number of patients was not able to be recruited during the period. Less

本研究的目的是利用18F-FDG-PET对接受辅助化疗的乳腺癌患者的认知功能进行测量，分析认知障碍随时间的变化，并检查患者的认知障碍是否与脑神经功能下降有关。公共卫生研究中心伦理审查委员会、日本大学板桥医院和三井纪念医院从PET检查的侵袭性和数据保密性方面进行了审查。开始招募能够手术并在医疗机构进行辅助化疗的女性乳腺癌患者。有两个测量点，新辅助化疗前和新辅助化疗后一个月。在每个测量点，我们执行：1)访谈和临床信息收集…更多的检查，2)月经情况问题，3)血检和尿检，4)一般健康状况检查(ECOG-PSR)，5)不良事件检查(CTC)。患者自己回答：1)健康相关生活质量问卷(EORTC QLQ C-30)，2)认知功能测试(WAIS-R)，3)抑郁状态和情绪障碍检查表(POMS)，也摆在研究者面前。随后，患者被送往东京大学医院，进行PET脑功能成像。另一项针对健康女性的研究与乳腺癌患者的检查同时进行，以证实WAIS-R的学习效果，并对测量结果进行调整。对5名同龄健康女性进行测量，收集研究室医疗机构的调查结果，并对数据进行研究分析。即使在科学研究补助资助期结束后，研究方案仍在继续，增加了招募病人的医疗机构的数量，因为在此期间未能招募到足够数量的病人。较少