Cognitive function of breast cancer patients after adjuvant chemotherapy-Measurement by F-fluorodeoxyglucose positron emission tomography(FDG-PET)

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The purposes of this research are in the measurement of the cognitive function of breast cancer patients who receive adjuvant chemotherapy, the analysis of a change over time of the cognitive impairment, and the examination whether patient's cognitive impairment is related to a decrease in the function of the cranial nerve by using 18F-FDG-PET.A detailed research protocol and the questionnaire were made before the commencement of this research. Ethical Review Board of the Public Health Research Center, the Nihon University Itabashi Hospital and the Mitsui Memorial Hospital, examined them in terms of the invasiveness of PET examination and data confidentiality.The recruitment of female primary breast cancer patients who were able to be operated and had an adjuvant chemotherapy in the medical institutions started.There are two measurement points, before and one month after the neo-adjuvant chemotherapy. In each measurement point, we perform ; 1) an interview and clinical information coll … More ection, 2) questions on menstruation situation, 3) blood test and urine test, 4) general health condition check (ECOG-PSR), and 5) adverse events check (CTC). The patient himself answers, to ; 1) health-related QOL questionnaire (EORTC QLQ C-30), 2) cognitive function test (WAIS-R), and 3) depression state and mood disorders checklist (POMS), in front of the investigator as well. Afterwards, the patient is transported to the University of Tokyo Hospital, for imaging the brain function by PET.Another study with healthy women runs side by side with the examination on the breast cancer patient to confirm the learning effect of WAIS-R, and to adjust the measurement results. This measurement was performed to five healthy women of the same age group.The investigation results are collected from the medical institutions in the research office, and the research analysis is done on the data. The research protocol continues even after the end of the subvention period of the Grant-in aid for scientific research, increasing the number of medical institutions for recruitment of the patients, because enough number of patients was not able to be recruited during the period. Less