Impact of Desulfovibrio spp. and sulfur metabolism on the pathogenesis of chronic intestinal inflammation and colitis-associated cancer (P18#)

我们最近将脱硫弧菌属，人类肠道中的主要硫酸盐还原菌（SRB），以及与慢性炎症性肠病患者的活动性疾病和复发相关的硫代谢。然而，目前缺乏充分表征的人类脱硫弧菌分离株和参考基因组，阻碍了发现它们在疾病相关机制中的潜在作用。在这个项目中，我们将分离人类SRB菌株，并表征其功能和菌株多样性。我们将利用这些信息来确定潜在的疾病相关机制，计算基于多组学数据分析和实验在结肠炎和结肠炎相关癌症的gnotobiotic小鼠模型。

We recently linked Desulfovibrio spp., the main sulfate reducing bacteria (SRB) in the human gut, and associated sulfur metabolism to active disease and relapse in chronic inflammatory bowel disease patients. However, the current lack of well-characterized human Desulfovibrio isolates and reference genomes, hinders the discovery of their potential role in disease-related mechanisms. In this project, we will isolate human SRB strains and characterize their functional and strain diversity. We will use this information to identify potential disease-related mechanisms computationally based on multi-omics data analysis and experimentally in gnotobiotic mouse models of colitis and colitis-associated cancer.