Impact of Desulfovibrio spp. and sulfur metabolism on the pathogenesis of chronic intestinal inflammation and colitis-associated cancer (P18#)

我们最近将人类肠道中的主要硫酸盐还原细菌(SRB)--硫磺弧菌与慢性炎症性肠病患者的活动性疾病和复发联系起来。然而，目前缺乏具有良好特性的人类脱硫弧菌分离株和参考基因组，阻碍了它们在疾病相关机制中的潜在作用的发现。在这个项目中，我们将分离出人类SRB菌株，并对它们的功能和菌株多样性进行鉴定。我们将使用这些信息来识别潜在的疾病相关机制，通过计算基于多组学数据分析，并在结肠炎和结肠炎相关癌症的灵知菌小鼠模型中进行实验。

We recently linked Desulfovibrio spp., the main sulfate reducing bacteria (SRB) in the human gut, and associated sulfur metabolism to active disease and relapse in chronic inflammatory bowel disease patients. However, the current lack of well-characterized human Desulfovibrio isolates and reference genomes, hinders the discovery of their potential role in disease-related mechanisms. In this project, we will isolate human SRB strains and characterize their functional and strain diversity. We will use this information to identify potential disease-related mechanisms computationally based on multi-omics data analysis and experimentally in gnotobiotic mouse models of colitis and colitis-associated cancer.