Realizing Human Brain Stimulation of Deep Regions Based on Novel Personalized Electrical Computational Modelling

基于开发局部和深部脑刺激的个性化计算物理模型的目标，我们使用数值和实验技术相结合的方法来研究刺激剂量特性。这些实验表明，单个手指会聚集在大脑的一小块区域，以高分辨率显示出焦点的可能性。此外，对双侧大脑半球经颅刺激在下肢深皮质刺激中的应用提出了新的见解。最后，在与个性化脑刺激模拟器集成的微物理神经元模型的开发方面取得了进展，以研究干扰现象。

Based on the aim of developing a personalized computational physical model for focal and deep brain stimulation, we investigated stimulation dose characteristics using a combined approach of numerical and experimental techniques. The experiments showed the possibility of focal stimulation of individual hand fingers that are condensed in a small area of the brain demonstrating focality with high resolution. In addition, new insight into the dual-hemisphere transcranial stimulation application was presented for deep cortical stimulation of the lower limb. Finally, progress in the development of a micro-physical neuron model integrated with the personalized brain stimulation simulator was achieved to investigate interferential phenomena.