Realizing Human Brain Stimulation of Deep Regions Based on Novel Personalized Electrical Computational Modelling

基于新型个性化电计算模型实现人脑深部刺激

• 批准号: 22H03922
• 负责人: ゴメスタメス ホセデビツト
• 金额: $ 11.48万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2022
• 资助国家: 日本
• 起止时间: 2022-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-22H03922/
• 关键词: Brain Stimulation; Neural Engineering; Computational Biophysics; Medical Imaging; Interferential; Brain stimulation

Based on the aim of developing a personalized computational physical model for focal and deep brain stimulation, we investigated stimulation dose characteristics using a combined approach of numerical and experimental techniques. The experiments showed the possibility of focal stimulation of individual hand fingers that are condensed in a small area of the brain demonstrating focality with high resolution. In addition, new insight into the dual-hemisphere transcranial stimulation application was presented for deep cortical stimulation of the lower limb. Finally, progress in the development of a micro-physical neuron model integrated with the personalized brain stimulation simulator was achieved to investigate interferential phenomena.

基于开发局部和深部脑刺激的个性化计算物理模型的目标，我们使用数值和实验技术相结合的方法来研究刺激剂量特性。这些实验表明，单个手指会聚集在大脑的一小块区域，以高分辨率显示出焦点的可能性。此外，对双侧大脑半球经颅刺激在下肢深皮质刺激中的应用提出了新的见解。最后，在与个性化脑刺激模拟器集成的微物理神经元模型的开发方面取得了进展，以研究干扰现象。

项目成果

Aalto University(フィンランド)

阿尔托大学（芬兰）

Universidad Nacional de La Plata(アルゼンチン)

拉普拉塔国立大学（阿根廷）

Center for Frontier Medical Engineering, Chiba U.

千叶大学前沿医学工程中心

Evaluation of cortical electrostimulation thresholds in human for uniform magnetic field exposure at intermediate frequencies

中频均匀磁场暴露下人体皮质电刺激阈值的评估

• 发表时间: 2022
• 作者: J. Gomez-Tames;T. Tarnaud;A. Hirata;W. Joseph;and E. Tanghe
• 通讯作者: and E. Tanghe

Brain function mapping by TMS combining computational dosimetry and experiments

结合计算剂量测定和实验的 TMS 绘制脑功能图

• 发表时间: 2022
• 作者: K. Hikita;J. Gomez-Tames;A. Hirata
• 通讯作者: A. Hirata