Dissecting the molecular interplay between tumor cells and stroma in primary liver cancer (B08)

点击翻译按钮获取中文摘要

Project B08 (Longerich/Pellegrino; Dissecting the molecular interplay between tumor cells and stroma in primary liver cancer) has entered the SFB/TR 209 in late 2018 and analyses mechanisms underlying plasticity of liver cancer cells, which bear on tumor differentiation and therapy resistance. The project has identified candidate genes affecting liver cancer cell differentiation/plasticity by acting on tumor cells and/or tumor-associated stroma using exome/transcriptome sequencing of different liver cancer variants. In the new funding period the gain-of-function phenotypic driver candidates will be evaluated in mosaic mouse models and functionally characterized in vitro and in vivo with the aim to identify modes of interdependency between tumor cell plasticity and tumor-associated stroma and potential ways of intervention.