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心室壁の局所心筋機能の新しい総合的解析法の研究

心室壁局部心肌功能综合分析新方法的研究

基本信息

批准号：
05221233
负责人：
菅原基晃
金额：
$ 2.3万
依托单位：
Tokyo Women's Medical University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research on Priority Areas
财政年份：
1993
资助国家：
日本
起止时间：
1993 至无数据
项目状态：
已结题

项目摘要

病的心臓の病態の詳細な解析には、心室壁局所の機能を総合的に解析する必要がある。この局所機能解析法の開発が本研究の目的である。我々の方法は、心室壁の着目した局所の平均壁応力sigmaと壁厚Hの間の関係に基づくものである。左室圧、左室短軸内径、着目した局所の壁厚を同時測定し、得られたデータからsigma-log(1/H)関係を一心周期にわたって求めた〔sigma-ln(1/H)ループ〕。このsigma-ln(1/H)ループから、次の三つの指標を求めた。(1)局所仕事。sigma-ln(1/H)ループに囲まれた面積は、心筋の単位体積あたりの局所仕事(RWM)に等しい。(2)局所心筋収縮性。sigma-log(1/H)ループが変化する際に収縮末期sigma-log(1/H)関係を表す点は、同一直線上を移動する。この直線の傾きは、心臓の大きさに依存しない規格化された心筋収縮性を表す。(3)局所心筋機能曲線。RWMと拡張末期log(1/H)の関係は心臓のスターリングの法則に従い、局所心筋機能曲線を表す。(1)(2)の妥当性と有用性については、これまでに報告してきたが、今回は(3)について、イヌを用いた動物実験により、さらに詳しい解析を行った。その結果、局所心筋機能曲線は、極めて良い精度で直線に近似することができ、その傾きは(2)の局所収縮性の変化とともに変化する、またこの直線は、生理的な範囲内での大動脈圧変化の影響を受けない、ということが明らかとなった(研究発表参照)。従って、我々は、この局所心筋機能曲線(直線)の傾きを、新しい心収縮性の指標として提案する。これにより、我々のsigma-log(1/H)ループに基づく方法の有用性は、一層増すものと考える。

The detailed analysis of heart disease and the analysis of ventricular wall function integration are necessary. The purpose of this study is to develop a functional analysis method for the analysis of local functions. The relationship between the average wall force sigma and wall thickness H of the ventricular wall is discussed. Left ventricular pressure, left ventricular minor axis diameter and left ventricular wall thickness were measured simultaneously, and the sigma-log (1/H) relationship was obtained. The sigma-ln (1/H) is the index of three times. (1)Office. sigma-ln (1/H): area, unit volume, etc. (2)The heart muscles of the bureau are contracted. sigma-log (1/H) relation is expressed in terms of point shift and line shift. The linear inclination and the size of the center depend on the normalization and contraction of the center. (3)The functional curve of the central tendon. The relationship between RWM and log (1/H) at the end of tension is shown in the following table: (1)(2) The appropriateness and usefulness of the report are reflected in the report.(3) The appropriateness and usefulness of the report are reflected in the analysis of the report. The results show that the central muscle function curve is very accurate and straight line approximation is very accurate.(2) The central muscle contraction property is very accurate and straight line approximation is very accurate.(3) The central muscle function curve is very accurate and straight line approximation is very accurate.(4) The central muscle contraction property is very accurate and straight line approximation is very accurate.(5) The central muscle function curve is very accurate and straight line approximation is very accurate.(6) The central muscle function curve is very accurate and straight line approximation is very accurate.(7) The central muscle contraction property is very accurate and straight line approximation is very accurate.(8) The central muscle function curve is very accurate and straight line approximation is very accurate.(9) The central muscle function curve is very accurate and straight line approximation is very accurate.(8) The central muscle function curve is very accurate and straight line approximation is very accurate.(9) The central muscle function curve is very accurate and straight line approximation is very accurate.(9) The central muscle function curve is very accurate and straight line approximation is very accurate and straight line approximation.(9) The central muscle function curve is very accurate and straight line approximation.( A new index of central contractibility is proposed for the curve (straight line) of central muscle function. The sigma-log (1/H) method is useful for the analysis.