Molecular Recognition of Reactive Organometallics

本课题组的研究重点是具有特殊功能的新型有机金属化合物的设计及其分子识别原理。成功合成了酪氨酸羟化酶和多巴胺-羟化酶的化学模型配合物，并阐明了反应机理。一种新的锰氧配合物被发现表现出热变色，这是由于配位的二氧与配体之间存在或不存在氢键造成的。采用光活性引发剂（Okamorto）合成了一组具有单手螺旋构象的光活性聚合物。制备了一系列pi-烯丙基钯配合物，并测定了它们的配位结构和反应活性（Kurosawa）。证明了卟啉金属配合物对核苷酸的分子识别，并确定了它们与核碱基的结合常数（Kuroda）。具有调节结构的卟啉复合物的分子组装被发现对氧具有良好的分子识别能力（Tsuchida）。证明了钴配合物催化的自扩增模型，并确定了加合物的形成常数（Yotsuyanagi）。

The investigation of the group has been focused to the dsign of novel organometallics having special functions and the priciples of their molecular recognitions.Chemical model comlexes of tyrosine hydroxylase and dopamine beta-hydroxylase were successfully synthesized and the reaction mechanism was elucidated. A novel manganese dioxygen complex was found to show thermocromism which is resulted from the presence or absence of hydrogen bond between coordinated dioxygen and ligand (Moro-oka). A group of optically active polymers with one-handed helical conformation were synthesized using optically active initiators (Okamorto). A series of pi-allyl palladium complexses were prepared and their coordination structure and reactivity were determined (Kurosawa). Molecular recognition of nucleotide coordinated on porphyrin metal complexes was demonstrated and their association constants for nucleobases were determined (Kuroda). Molecular assembly of porphyrin complex having regulated structure was found to show excellent molecular recognition towards oxygen (Tsuchida). Auto-amplification model of catalysis by cobalt complexes was demonstrated and adduct formation constants were determined (Yotsuyanagi).