Noninvasive measurement of human body temperatures using high field magnetic resonance spectroscopy

在这项研究中，我们尝试使用磁共振波谱（^1H-MRS）在3 t下无创测量正常休息的成年志愿者的区域温度，并利用水质子相对于代谢物质子的磁共振化学位移来估计温度。1名男性（48岁）反复测量脑区域温度，结果表明，使用^1H MRS测量脑温度，误差范围小于0.2。36名志愿者（19 ~ 65岁）中，18名男性左扣带区和额叶附近深部白质温度分别为37.4±0.4和37.0±0.6（均数±标准差显著差异，配对t检验，P<0.05）。18名女性分别为37.4±0.4和37.4±0.6℃，差异无统计学意义。雄鼠额叶温度显著低于雌鼠（P <0.05）。此外，雄鼠深层白质温度与鼓室温度显著相关（r = 0.809, P <0.001）。小腿肌肉温度在环境温度（21 ~ 25）下，腓肠肌（GAS；壳区）和比目鱼肌（SOL；核心区）的温度分别为35.5±1.5和37.4±1.6 (mean±SD)，差异有统计学意义（P <0.01）。下肢表面温度从40到10的交替使GAS的温度从38.1±1.2显著改变为28.0±3.8 (P <0.0001)，而SOL的温度不受此操作的显著影响。在生理条件下，我们可以使用H磁共振波谱（^1H-MRS）无创测量深部温度。

In this study, we tried to measure the regional temperatures noninvasively in normal resting adult volunteers using 'H magnetic resonance spectroscopy (^1H-MRS) at 3 T. The temperature was estimated by using the magnetic resonance chemical shift of water protons relative to protons of metabolites.1. BRAIN TEMPERATURERepeatedly measured regional brain temperature in one male (48 years old) indicated that the brain temperature could be measured using ^1H MRS with an error range of less than 0.2 Among 36 volunteers (19 -65 years old), values of the temperature at deep white matter near the left cingulate gyms and frontal lobe in 18 males were 37.4±0.4 and 37.0±0.6 (mean±SD significantly different, paired t-test, P<0.05), and those in 18 females were 37.4±0.4 and 37.4±0.6℃ (not significantly different). The temperature at the frontal lobe in the males was significantly lower than that in the females (P <0.05). Moreover, the temperature at the deep white matter in the males, but not in the females, significantly correlated with tympanic temperature (r = 0.809, P <0.001).2. TEMPERATURE OF LOWER LEG MUSCLESThe values of temperature in gastrocnemius (GAS; shell region) and soleus muscles (SOL; core region) at ambient temperature (21 -25 were estimated to be 35.5±1.5 and 37.4±1.6 (mean±SD), respectively (significantly different; P <0.01). Alternation of the surface temperature of the lower leg from 40 to 10 significantly changed the temperature in GAS (P <0.0001) from 38.1±1.2 to 28.0±3.8 However, the temperature in SOL was not significantly affected by this maneuver. 1 We could measure the temperatures at deep regions noninvasively using H magnetic resonance spectroscopy (^1H-MRS) under physiological conditions.