Mitochondrial pathway of apoptosis in target organs of sex steroid hormones

性类固醇激素靶器官凋亡的线粒体途径

• 批准号: 14570207
• 负责人: TERADA Nobuyuki
• 金额: $ 1.79万
• 依托单位: Hyogo College of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2004
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570207/
• 关键词: apoptosis; mitochondria; VDAC; fos; Shionogi carcinoma 115; stroma; seminal vesicle; epididymis; エストロゲン; 子宮; c-fos; 前立腺; 凝固腺; ホルモン依存性癌; 性嚢; チトクロームC; Bcl-2ファミリー; caspase

1)We have shown that the mitochondrial pathway of apoptosis which is regulated by Bcl-2 family proteins, works in uterine epithelial apoptosis after cessation of estrogen stimulation and that number of mitochondrial voltage-dependent anion channel increases, promoting epithelial apoptosis.2)We have shown that the mitochondrial pathway of apoptosis works in apoptosis of androgen-dependent Shionogi 115 carcinoma cells after deprivation of androgen in vito.3)We have shown that fos plays no role in apoptosis of epithelia in the mouse male accessory sex organs and uterus.4)We have shown that degree of epithelial apoptosis in the seminal vesicle or epididymis is much lower during the prepubertal period than after the prepubertal period.5)We established the experimental systems with which we can examine the effect of stromal area on uterine epithelial apoptosis.

1）我们已经表明，由Bcl-2家族蛋白调节的线粒体凋亡途径在雌激素刺激停止后的子宫上皮细胞凋亡中起作用，并且线粒体电压依赖性阴离子通道的数量增加，促进上皮细胞凋亡。2）我们已经表明，线粒体凋亡途径在雄激素细胞凋亡中起作用，3）Fos在小鼠雄性附性器官和子宫上皮细胞凋亡中不起作用。我们已经发现，青春期前的精囊或附睾上皮细胞凋亡程度比青春期后低得多。我们建立了一个实验系统，我们可以用它来研究基质面积对子宫上皮细胞凋亡的影响。

项目成果

Castration induces apoptosis in the mouse epididymis during postonatal development.

去势会在产后发育过程中诱导小鼠附睾凋亡。

• 发表时间: 2002
• 期刊: Endocrine Journal 49
• 作者: Takgi-Morishita Y.;Kuhara A.;Sugihara A.;Yamada N.;Yamamoto R.;Iwasaki T.;Tsujimura T.;Tanji N.;Terada N.
• 通讯作者: Terada N.

Mouse uterine epithelial cell apoptosis is associated with expression of mitochondrial voltage-dependent anion channels, release of cytochrome c from mitochondria and the ratio of bax to bcl-2 or bcl-x.

小鼠子宫上皮细胞凋亡与线粒体电压依赖性阴离子通道的表达、线粒体细胞色素c的释放以及bax与bcl-2或bcl-x的比率相关。

• 发表时间: 2003
• 期刊: Biology of Reproduction 68
• 作者: Takagi-Morishita;Y.;et al.
• 通讯作者: et al.

Y.Takagi-Morishita, N.Terada et al.: "Mouse uterine epithelial apoptosis is associated with expression of mitochondrial voltage-dependent anion channels, release of cytochrome C from mitochondria, and the ratio of bax to bcl-2 or bcl-X"Biology of Reproduc

Y.Takagi-Morishita、N.Terada 等人：“小鼠子宫上皮细胞凋亡与线粒体电压依赖性阴离子通道的表达、线粒体细胞色素 C 的释放以及 bax 与 bcl-2 或 bcl-X 的比率相关

Fos plays no role in apoptosis of epithelia in the mouse male accessory sex organs and uterus.

Fos 在小鼠雄性副性器官和子宫的上皮细胞凋亡中没有作用。

• 发表时间: 2005
• 期刊: Endocr J. 52(1)
• 作者: Oh EH;Hirose M;Takemura T;Yoshihara H;Ishizaki T;Imanaka Y.;Kuhara A
• 通讯作者: Kuhara A

Takagi-Morishita Y., Yamada N., Sugihara A., Terada N., et al.: "Mouse uterine epithelial apoptosis is associated with expression of mitochondrial voltage-dependent anion channels, release of cytochrome c from mitochondria, and the ratio of Bax to Bcl-2 o

Takagi-Morishita Y.、Yamada N.、Sugihara A.、Terada N. 等人：“小鼠子宫上皮细胞凋亡与线粒体电压依赖性阴离子通道的表达、线粒体中细胞色素 c 的释放以及